Teratogenic Effect of Dopamine on the Embryonic Chick Heart.
- Author:
Bon Seok KOO
1
;
Nam Su KIM
;
Yong Joo KIM
;
Sung Yup MOON
;
Hang LEE
Author Information
1. Department of Pediatrics, College of Medicine, Hanyang University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Teratogenic effect;
Dopamine;
Chick;
Embryo;
Heart anomaly;
Ventricular septal defect
- MeSH:
Animals;
Aorta, Thoracic;
Bays;
Chick Embryo;
Dopamine*;
Embryonic Structures;
Heart Septal Defects, Ventricular;
Heart*;
Incubators;
Morphogenesis;
Sodium Chloride;
Survival Rate
- From:Journal of the Korean Pediatric Society
2000;43(7):913-919
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To investigate the teratogenic potential of dopamine using a topical method of application to the developing Korean native chick embryo. METHODS: A 5 pg(0.05cc) of dopamine was applied to a 3-days-old chick embryo and the same amount of saline solution was applied as control. The embryo was then returned to the incubator and monitored. After 3 weeks the embryo was sacrificed and examined for cardiovascular malformation. RESULTS: The survival rate of the dopamine-administered group was not significantly lower than that of the control group(32.2% vs 41.5%). Cardiovascular malformation rates between the two groups were 14.3% and 2.6%, respectively. The dopamine-administered group had significant higher malformation rate(P=0.049). The type of malformation was ventricular septal defect and no aortic arch anomaly. In the control group, one trabecular type was observed. In the dopamineadministered group, malformations were 3 trabecular ventricular septal defects(VSDs), 2 infracrista VSDs, 1 inlet VSD and 1 large supracrista VSD. These results were quite different from each other. CONCLUSION: We proposed that low doses of dopamine influence the cardiovascular morphogenesis through -1 receptor weakly or through dopaminergic receptor.
