Two Cases of Thin Basement Membrane Nephropathy presented with Minimal Change Nephrotic Syndrome.
- Author:
Young Mee SEO
1
;
Jae Gul CHUNG
;
En Sil YU
;
Jin Yeong JEONG
;
Young Seo PARK
Author Information
1. Department of Pediatrics, Asan Medical Center.
- Publication Type:Case Report
- Keywords:
Thin basement membrane nephropathy;
Minimal change nephrotic syndrome
- MeSH:
Basement Membrane*;
Complement System Proteins;
Fluorescent Antibody Technique;
Hematuria;
Immunoglobulins;
Microscopy, Electron;
Nephritis, Hereditary;
Nephrosis, Lipoid*;
Nephrotic Syndrome;
Proteinuria
- From:Journal of the Korean Pediatric Society
2000;43(7):978-982
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Thin basement membrane nephropathy(TBMN) is defined histologically as follows: 1) By light rnicroscopy only minor abnormalities are detected in the glomeruli at most minor mesangial widening. 2) By electron microscopy, diffuse thinning of glomerular basement rnembrane is demonstrated. 3) By immunofluorescence, absence of immunoglobulins and complement components is demonstrated. 4) Alport's syndrome and systemic diseases that may affect the glomerular structure have been excluded. TBMN presented frequently with recurrent or persistent microscopic hematuria. Massive proteinuria such as in nephrotic syndrome rarely occurs in TBMN. We reported two cases of TBMN presented with typical minimal change nephrotic syndrome.
