Resveratrol attenuates aging-induced mitochondrial dysfunction and mitochondria-mediated apoptosis in the rat heart
- Author:
Youngju CHOI
1
;
Mi-Hyun NO
;
Jun-Won HEO
;
Eun-Jeong CHO
;
Dong-Ho PARK
;
Ju-Hee KANG
;
Chang-Ju KIM
;
Dae Yun SEO
;
Jin HAN
;
Hyo-Bum KWAK
Author Information
- Publication Type:Original Research
- From:Nutrition Research and Practice 2025;19(2):186-199
- CountryRepublic of Korea
- Language:English
-
Abstract:
RESULTS:Resveratrol significantly reduced cardiac hypertrophy and remodeling in aging hearts. In addition, resveratrol significantly ameliorated aging-induced mitochondrial dysfunction (e.g., decreased oxygen respiration and increased hydrogen peroxide emission) and mitochondria-dependent apoptotic signaling (the Bax/Bcl-2 ratio, mitochondrial permeability transition pore opening sensitivity, and cleaved caspase-3 protein levels).Resveratrol also significantly attenuated aging-induced apoptosis (determined via cleaved caspase-3 staining and TUNEL-positive myonuclei) in cardiac muscles.
CONCLUSION:This study demonstrates that resveratrol treatment has a beneficial effect on aging-induced cardiac remodeling by ameliorating mitochondrial dysfunction and inhibiting mitochondria-mediated apoptosis in the heart.
