Clinicopathologic Features of Colorectal Cancer with Liver Metastases.
- Author:
Sun Keun CHOI
1
;
Yong Sun JEON
;
Sun Young BAE
;
Min Keun KWAK
;
Yoon Seok HUR
;
Keon Young LEE
;
Sei Joong KIM
;
Young Up CHO
;
Seung Ik AHN
;
Kee Chun HONG
;
Seok Hwan SHIN
;
Kyung Rae KIM
;
Ze Hong WOO
Author Information
1. Departments of Surgery, Inha University College of Medicine, Korea. woopark@inha.ac.kr
- Publication Type:Original Article
- Keywords:
Colorectal cancer;
Liver metastases;
Vascular invasion;
Lymph node invasion
- MeSH:
Colorectal Neoplasms*;
DNA;
Follow-Up Studies;
Humans;
Liver*;
Lymph Nodes;
Multivariate Analysis;
Neoplasm Metastasis*;
Ploidies;
Retrospective Studies
- From:Journal of the Korean Society of Coloproctology
2004;20(4):211-217
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The aim of this study was to clarify the clinicopathologic features in colorectal cancer with liver metastases and to evaluate their clinical significance. METHODS: From August 1996 to April 2002, 545 patients, who underwent radical surgery for primary colorectal cancers, were analyzed retrospectively. RESULTS: Colorectal cancers with and without synchronous liver metastases at the time of the surgery were 36 and 509 cases, respectively. Of the 509 cases without metastases, 34 cases had metachronous liver metastases by April 2002, but the others did not. Serosal, vascular, perineural, and lymph node invasions, as well as increased preoperative CEA levels, were more frequently observed in those with synchronous liver metastases than it was in those without metastases (P<0.05). According to multivariate analyses, lymph node invasion was statistically significant as an independent variable in those with synchronous metastases (P=0.009). Serosal, vascular, and lymph node invasions, increased preoperative CEA levels, DNA ploidy, and positive lateral resection margins were more frequently observed in those with metachronous liver metastases than it was in those without metastases (P<0.05). According to multivariate analyses, vascular invasion was statistically significant in those with metachronous metastases (P=0.015). CONCLUSIONS: Lymph node and vascular invasions appear to be significant determinants for synchronous and metachronous liver metastases in colorectal cancers. Therefore, close observation and careful postoperative follow-up is needed for such patients.
