Review of Clinical Research Articles on Kampo Medicines and Oral Antiviral Drugs for Acute-phase Treatment of COVID-19
- VernacularTitle:COVID-19急性期治療に対する漢方薬と経口抗ウイルス薬治療の臨床研究論文レビュー
- Author:
Airi TAKAGI
1
;
Shin TAKAYAMA
2
Author Information
- Keywords: COVID-19; Kampo medicine; clinical trial; observational research
- From:Kampo Medicine 2024;75(2):168-175
- CountryJapan
- Language:Japanese
- Abstract: As part of the studies to build evidence for the coronavirus disease-2019 (COVID-19) conducted by the Japan Society for Oriental Medicine, the observational research and the clinical trials were designed to examine the effectiveness of Kampo medicine in the treatment of COVID-19. These studies were initiated in the context of limited information about the clinical findings of COVID-19 and previous clinical study. Therefore, through literature review, we compared these studies with clinical trials on oral antiviral drugs in terms of endpoint, analysis methods, and results. Results of this review showed that the rate of severe disease and time to symptoms relief, which were focused on in observational research and clinical trials of Kampo medicines, were also used in antiviral drug trials. Furthermore, we discussed that when interpreting the results of clinical studies, it was important to take into account factors that may affect the results, such as the number of cases, the characteristics of the endpoint, and the characteristics of the target population.
