Problems of polypharmacy in Kampo preparations

Toshiaki MAKINO; Mariko SEKINE; Saori SHIMADA; Koichiro TANAKA; Atsushi CHINO; Eiichi TAHARA; Shigeki NABESHIMA

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Problems of polypharmacy in Kampo preparations

VernacularTitle:漢方診療における漢方製剤の多剤併用（ポリファーマシー）の問題～医療安全委員会報告～
Author: Toshiaki MAKINO ¹ ; Mariko SEKINE ² ; Saori SHIMADA ³ ; Koichiro TANAKA ⁴ ; Atsushi CHINO ⁵ ; Eiichi TAHARA ⁶ ; Shigeki NABESHIMA ⁷
Author Information

1. Department of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Nagoya City University
2. Department of Research, Kitasato University Kitasato Institute Hospital
3. Department of Pharmacy, University of Tsukuba Hospital
4. Department of Traditional Medicine, Faculty of Medicine, Toho University
5. Department of Japanese Oriental (Kampo) Medicine, Chiba Central Medical Center
6. Department of Japanese Oriental (Kampo) Medicine, Aizu Medical Center, Fukushima Medical University
7. Department of General Medicine, Faculty of Medicine, Fukuoka University
Keywords: receipt data; Kampo preparations; crude drugs; duplication
From:Kampo Medicine 2024;75(2):144-151
CountryJapan
Language:Japanese
Abstract: We analyzed dispensing receipt data in the medical treatment in October 2019 using the Receipt Information/Specific Medical Examination Information National Database (NDB), extracted the cases of multiple combinations of Kampo prescriptions, and analyzed their frequencies. Of the 536,524 receipts, 44,731 (8.3%) included Kampo and non-Kampo crude drug preparations. Of the receipts that included Kampo and non-Kampo crude drug preparations, 38,032 receipts (7.1%) included single Kampo or non-Kampo crude drug preparation. There were 6,699 receipts (1.2%) that included multiple Kampo and non-Kampo crude drug preparations. There were 187 receipts for the decoctions containing multiple rude drugs without Kampo preparations, and the ratio was 0.035% of all receipts and 0.42% of the receipts containing Kampo and non-Kampo crude drug preparations. There was one receipt containing eight Kampo preparations, three receipts containing seven Kampo preparations, and a total of 84 receipts containing five or more Kampo preparations. Although it is unclear how many multiple Kampo preparations were prescribed at the same time, this investigation indicates the actual duplication of multiple Kampo preparations.