Analysis of Clinical Features and Factors Predictive of Malignancy in Intraductal Papillary Mucinous Tumor of the Pancreas: Multi-center Analysis in Korea.
- Author:
Jin Young JANG
1
;
Sun Whe KIM
;
Young Joon AHN
;
Yoo Seok YOON
;
Kuhn Uk LEE
;
Young Joo LEE
;
Song Chul KIM
;
Gee Hun KIM
;
Duck Jong HAN
;
Yong Il KIM
;
Seong Ho CHOI
;
Baik Hwan CHO
;
Hee Chul YU
;
Byong Ro KIM
;
Dong Sup YOON
;
Woo Jung LEE
;
Kyung Bum LEE
;
Young Chul KIM
;
Kwang Soo LEE
;
Kyeong Geun LEE
;
Young Kook YUN
;
Soon Chan HONG
;
Koo Jeong KANG
;
Tae Jin LIM
;
Kyong Woo CHOI
;
Yong Oon YOO
;
Jong Hun PARK
;
Young Hoon KIM
;
Mun Sup SIM
;
Hyung Chul KIM
;
Chang Ho KIM
;
Man Kyu CHAE
;
Hong Yong KIM
;
Young Gil CHOI
;
Wook Hwan KIM
;
Myung Wook KIM
;
Hong Jin KIM
;
Kwon Mook CHAE
;
Dong Wook CHOI
;
Sang Beom KIM
;
Ho Seong HAN
;
Seung Ik AHN
;
Kuk Hwan KWON
;
Chul Gyun JO
;
Hyun Jong KIM
;
Jae Woon CHOI
;
Jong Riul LEE
;
Joo Seop KIM
;
Yong Hyun PARK
Author Information
- Publication Type:Multicenter Study ; Original Article
- Keywords: Intraductal papillary mucinous tumor; IPMT; Malignancy prediction
- MeSH: Academies and Institutes; Diagnosis; Dilatation; Female; Humans; Korea*; Male; Mucins*; Multivariate Analysis; Pancreas*; Pancreatectomy; Pancreatic Neoplasms; Pancreaticoduodenectomy; Prognosis; Retrospective Studies
- From:Korean Journal of Hepato-Biliary-Pancreatic Surgery 2003;7(1):1-11
- CountryRepublic of Korea
- Language:Korean
- Abstract: BACKGROUND/AIMS: Despite of increasing numbers of reports on intraductal papillary mucinous tumor (IPMT), there is still difficulty in its' diagnosis, treatment and prediction of prognosis. The purpose of this multicenter study was to evaluate the clinico-pathological features of IPMT in Korea and suggest the prediction criteria of malignancy in IPMT. METHODS: We retrospectively reviewed the clinico-pathological data of 208 patients who underwent operations with IPMT between 1993 and 2002 at 28 institutes in Korea. RESULTS: Of the 208 patients with a mean age of 60.5+/-9.7 years, 147 were men and 61 were women. 124 patients underwent pancreatoduodenectomy, 42 distal pancreatectomy, 17 total pancreatectomy, 25 limited pancreas resection. Benign cases were 128 (adenoma (n=62), borderline (n=66)) and malignant cases were 80 (non-invasive (n=29), invasive (n=51)). A significant difference in 5-year survival was observed between benign and malignant group (92.6% vs. 65.3%; p=0.006). Of the 6 factors (age, location, duct dilatation, tumor appearance, main duct type, and tumor size) that showed the statistical difference in univariate analysis between benign and malignant group, we found three significant factors (tumor appearance (p=0.009), tumor size (p=0.023), and dilated duct size (p=0.010)) by multivariate analysis. CONCLUSION: Although overall prognosis of IPMT is superior to ordinary pancreatic cancer, more curative surgery is recommended in malignant IPMT. Tumor appearance (papillary), tumor size (> or =30 mm) and dilated duct size (> or = 12 mm) can be used as preoperative indicators of malig-nancy in IPMT.
