Research progress on the role of NF-κB signaling pathway in acute lung injury and TCM intervention
- VernacularTitle:NF-κB信号通路在急性肺损伤中的作用及中药干预研究进展
- Author:
Fuli LIU
1
;
Yuanming BA
2
Author Information
1. College of TCM，Hubei University of Chinese Medicine，Wuhan 430061，China
2. Dept. of Nephrology，the Affiliated Hospital of Hubei University of Chinese Medicine，Wuhan 430061，China
- Publication Type:Journal Article
- Keywords:
NF-κB signaling pathway;
acute lung injury;
traditional Chinese medicine;
mechanism
- From:
China Pharmacy
2025;36(10):1277-1282
- CountryChina
- Language:Chinese
-
Abstract:
Acute lung injury （ALI） is a common clinical inflammatory respiratory emergency with high morbidity and mortality， for which there is no effective and safe therapeutic drug. Nuclear factor-κB （NF-κB）， as a classic inflammatory signaling pathway， can interact with upstream and downstream regulatory factors such as Toll-like receptor 4 （TLR4）， mitogen- activated protein kinase （MAPK）， nucleotide-binding domain leucine-rich repeat and pyrin domain-containing receptor 3 （NLRP3）， high mobility group box-1 protein 1 （HMGB1）， to jointly affect ALI. This review summarizes the latest research findings in recent years regarding the treatment of ALI through traditional Chinese medicine （TCM） interventions targeting NF-κB signaling pathways. It has been found that a variety of TCM monomers （danshensu methyl ester， salidroside total glycosides， berberine， Codonopsis pilosula polysaccharides， ursolic acid， chrysophanol， and polyphenols from longan seed kernels， etc.） and compound formulas （Resolving-dampness and defeating-toxins formula， Jinyin qingre oral liquid， Xuebijing injection， Combined treatment of lung and intestine， Huangqi baihe decoction， etc.） can modulate NF-κB signaling pathway， and can prevent and control ALI by inhibiting inflammation， improving oxidative stress， reducing apoptosis and modulating the intestinal flora in a multi-pathway manner.
