Dosimetric comparison of the heart and its substructures between two hybrid radiotherapy plans following breast-conserving surgery for left-sided breast cancer
10.13491/j.issn.1004-714X.2025.02.005
- VernacularTitle:左侧乳腺癌保乳术后两种混合计划的心脏剂量学比较
- Author:
Lin GUO
1
;
Hongrong REN
1
;
Meng CHEN
1
;
Chengjun WU
1
;
Yun ZHOU
1
;
Xiaobo RUAN
1
;
Ji DING
1
;
Weiyuan WU
1
Author Information
1. Department of Radiotherapy, Xuzhou Central hospital, Xuzhou 221000 China.
- Publication Type:OriginalArticles
- Keywords:
Early-stage left-sided breast cancer;
Hypofractionated whole-breast radiotherapy;
Hybrid radiotherapy plan;
Heart and its substructures;
Dosimetric comparison
- From:
Chinese Journal of Radiological Health
2025;34(2):174-178
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the dosimetric differences in the heart and its substructures between two hybrid plans for hypofractionated whole-breast radiotherapy after breast-conserving surgery in patients with early-stage left-sided breast cancer. Methods A total of 46 patients with early-stage left-sided breast cancer who underwent hypofractionated whole-breast radiotherapy were randomly selected. Two hybrid radiotherapy plans were used, including hybrid intensity-modulated radiotherapy (H_IMRT) and hybrid volumetric-modulated arc therapy (H_VMAT). The heart and its substructures were contoured, including left anterior descending (LAD), left ventricle (LV), right coronary artery (RCA), and right ventricle (RV). The heart and substructure doses, as well as monitor units, were compared between H_IMRT and H_VMAT. Results Both hybrid plans met the clinical requirements. H_IMRT significantly outperformed H_VMAT for the heart (V10, V30, and Dmean), LAD (V30, V40, Dmax and Dmean), LV (V10, V20 and Dmean), RCA (Dmax, Dmean), and RV (V5, V10, Dmean) (P < 0.001). Additionally, H_IMRT was significantly superior to H_VMAT for heart V5, LAD V20, and RV V20 (P = 0.005, 0.035 and 0.037). For LAD (V15, V40) and LV (V5, V25), H_IMRT was slightly better than H_VMAT, and the difference was not statistically significant. Conclusion Both H_IMRT and H_VMAT hybrid radiotherapy plans are suitable for hypofractionated whole-breast radiotherapy after breast-conserving surgery in patients with early-stage left-sided breast cancer. H_IMRT is slightly better than H_VMAT in dose sparing for the heart and its substructures.
