CD36-mediated immune response and transfusion safety
10.13303/j.cjbt.issn.1004-549x.2025.05.007
- VernacularTitle:CD36介导的免疫反应与输血安全
- Author:
Xiaomei JIE
1
;
Ziyi HE
1
;
Yingming HU
1
;
Menghui BEI
1
Author Information
1. Dongguan Central Blood Station, GuangdongDongguan 523000, China
- Publication Type:Journal Article
- Keywords:
CD36;
immune response;
transfusion-related immunomodulation;
transfusion safety;
blood transfusion strategy
- From:
Chinese Journal of Blood Transfusion
2025;38(5):637-643
- CountryChina
- Language:Chinese
-
Abstract:
Cluster of differentiation 36 (CD36) is a highly glycosylated double transmembrane glycoprotein, which is involved in the inflammatory response and immune regulation of the body. It plays a key role in mediating the mechanism of immune-related blood transfusion reactions and regulating the function of immune cells. It has an important impact on blood transfusion safety and has become a current research hotspot. This article reviews and comprehensively analyzes the research progress of the specific role of CD36 in the immune response of blood transfusion and its regulatory mechanism at home and abroad. Combined with clinical cases and experimental data, the pathophysiological mechanism of CD36 in immune response and its immune-mediated blood transfusion safety issues are reviewed. It is expected to provide new theoretical support and practical guidance for the field of blood transfusion safety and promote the further development of blood transfusion medicine.
