Regulation of Ferroptosis by Traditional Chinese Medicine for Colorectal Cancer Intervention： A Review
10.13422/j.cnki.syfjx.20242223
- VernacularTitle:中药调控铁死亡干预结直肠癌的研究进展
- Author:
Xiangchen LIU
1
;
Weihan ZHAO
2
;
Feixue FENG
2
;
Xiaodong YANG
2
;
Zhilong ZHAO
1
;
Dezhen YANG
2
Author Information
1. The First School of Clinical Medicine， Shaanxi University of Chinese Medicine， Xianyang 712000， China
2. Affiliated Hospital of Shaanxi University of Chinese Medicine， Xianyang 712000， China
- Publication Type:Journal Article
- Keywords:
colorectal cancer;
ferroptosis;
traditional Chinese medicine;
mechanism;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(12):276-286
- CountryChina
- Language:Chinese
-
Abstract:
Colorectal cancer （CRC） is a common malignant tumor of the digestive tract with high morbidity and mortality. Although existing treatments can prolong the survival of patients， problems such as low quality of life， obvious side effects， and unsatisfactory clinical efficacy still exist， which cannot fully satisfy the overall needs of patients. For this reason， it is crucial to explore the mechanism underlying the development of CRC and to identify new treatment strategies. In recent years， with the deepening of research， ferroptosis has been gradually proven to effectively inhibit the proliferation and metastasis of CRC cells， overcome tumor drug resistance， enhance anti-tumor efficacy， and prevent tumor progression and recurrence. Therefore， regulating ferroptosis is expected to become a new strategy for the treatment of CRC. Traditional Chinese medicine （TCM） has been widely used in CRC treatment due to its advantages of multiple components， multiple targets， low drug resistance， and few side effects， and has gradually become a current research hotspot. Extensive studies have shown that TCM active ingredients and compound formulae can regulate ferroptosis-related pathways， such as iron metabolism， lipid metabolism， the cystine/glutamate antiporter system Xc- （System Xc-）/glutathione （GSH）/glutathione peroxidase 4 （GPX4）， ferroptosis suppressor protein 1 （FSP1）/coenzyme Q10 （CoQ10）/nicotinamide adenine dinucleotide phosphate ［NAD（P）H］， tumor protein 53 （p53）， nuclear factor erythroid-2-related factor 2 （Nrf2）， and non-coding RNA pathways to inhibit the growth and proliferation of CRC， thereby exerting anti-tumor effects. This review systematically summarized the mechanisms of ferroptosis related to CRC， therapeutic targets and prognosis-related markers associated with ferroptosis in CRC， and research progress on TCM targeting and regulating ferroptosis for CRC intervention， aiming to provide new perspectives and a theoretical basis for the prevention and treatment of CRC with TCM.
