Analysis of Animal Model of Chronic Heart Failure Based on Combination of Diseases and Syndromes of Traditional Chinese Medicine and Western Medicine
10.13422/j.cnki.syfjx.20250793
- VernacularTitle:基于中西医病证结合特点的慢性心力衰竭动物模型分析
- Author:
Xueyan ZHANG
1
;
Kexin ZHANG
1
;
You YU
2
;
Huan ZHANG
1
;
Yingzhu DUAN
1
;
Rui YU
1
Author Information
1. Liaoning University of Chinese Medicine，Shenyang 110000，China
2. The Second Affiliated Hospital of Liaoning University of Chinese Medicine，Shenyang 110000，China
- Publication Type:Journal Article
- Keywords:
chronic heart failure;
animal model;
combination of disease and syndrome;
traditional Chinese medicine and Western medicine
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(12):239-247
- CountryChina
- Language:Chinese
-
Abstract:
Chronic heart failure （CHF） represents the terminal stage of cardiovascular diseases， and its prevalence remains high in China. In this study， existing animal models of CHF were retrieved and categorized. In combination with the characteristics of CHF from traditional Chinese medicine （TCM） and Western medicine perspectives， the models were weighted， and their clinical consistency was evaluated. The advantages and disadvantages of the models were assessed. Among them， models with higher TCM clinical consistency included the doxorubicin-induced model， the isoproterenol-induced model， and the left anterior descending coronary artery ligation model， each with a TCM consistency rate of 90%. The animal model established by the left anterior descending coronary artery ligation showed a high degree of clinical consistency with Western medicine， with a consistency rate of 82%. Each model exhibited its own advantages and disadvantages， with a general lack of modeling methods combining diseases and syndromes of TCM and Western medicine. At present， the inducement factors used for animal models are relatively singular， mainly reflecting the etiology and pathogenesis of Western medicine， with insufficient correlation to the pathogenesis of TCM. The characteristics of TCM syndromes are not fully represented， and the consistency between TCM and Western medicine is generally not high. TCM has the advantage of a multi-dimensional syndrome differentiation and treatment approach. It is necessary to integrate the characteristics of diseases and syndromes of TCM and Western medicine， adopt multi-factor modeling methods to reflect the pathological process of CHF， improve existing models， and establish animal models of CHF that better align with the characteristics of clinical diseases and syndromes of TCM and Western medicine， so as to provide a reliable reference for clinical prevention and treatment.
