Traditional Chinese Medicine Prevents and Treats Cerebral Ischemia-reperfusion Injury by Regulating Nrf2 Signaling Pathway： A Review
10.13422/j.cnki.syfjx.20242441
- VernacularTitle:中药调控Nrf2信号通路防治脑缺血再灌注损伤的研究进展
- Author:
Siqing WU
1
;
Jun WANG
1
;
Mingsan MIAO
1
;
Jinxin MIAO
1
Author Information
1. Henan University of Chinese Medicine， Zhengzhou 450046，China
- Publication Type:Review
- Keywords:
traditional Chinese medicine;
cerebral ischemia-reperfusion injury;
nuclear factor E2-related factor 2 （Nrf2） signaling pathway;
anti-oxidant;
anti-apoptosis
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(13):286-295
- CountryChina
- Language:Chinese
-
Abstract:
Cerebral ischemia-reperfusion injury （CIRI）， a common cerebrovascular disease damage， has garnered increasing attention in the treatment of acute ischemic stroke. Restoration of blood flow and reperfusion to ischemic brain tissue is the key to treatment， while this process often triggers a variety of complex pathophysiological responses， such as oxidative stress， apoptosis， inflammation， mitochondrial dysfunction， angiogenic abnormalities， and disruption of the blood-brain barrier. These responses not only impede the recovery of neurological functions but also may lead to damage or even death of nerve cells， seriously affecting the neurological function and quality of survival of patients. As an important transcription factor， nuclear factor E2-related factor 2 （Nrf2） has the pharmacological effect of alleviating CIRI by regulating antioxidant， anti-apoptosis， anti-inflammation， mitochondrial function， angiogenesis， and blood-brain barrier pathways. This reveals the potential mechanism of traditional Chinese medicine （TCM） in intervening in CIRI and shows the potential of Nrf2 as a new pathway for dealing with ischemia stroke. This paper comprehensively analyzes the effects and mechanisms of active components and compound prescription of TCM in treating CIRI by modulating the Nrf2 signaling pathway， while pointing out the shortcomings of available studies and proposing a multidimensional exploration. This review aims to provide patients with more comprehensive， safe， and effective therapeutic regimens and improve the quality of survival and prognosis of patients. In addition， in-depth research on TCM should be promoted to reveal the potential mechanism for treating CIRI， providing new ideas and directions for the development of novel therapeutic drugs and methods.
