Phase Change and Quantity-quality Transfer Analysis of Medicinal Materials， Decoction Pieces and Standard Decoction of Haliotidis Concha （Haliotis discus hannai）
10.13422/j.cnki.syfjx.20250468
- VernacularTitle:石决明（皱纹盘鲍）药材、饮片及标准汤剂的物相变化及量质传递分析
- Author:
Zhihan YANG
1
;
Jingwei ZHOU
1
;
Weichao WANG
1
;
Yu HUANG
2
;
Chuang LUO
1
;
Lian YANG
2
;
Chenyu ZHONG
1
;
Hongping CHEN
1
;
Fu WANG
1
;
Yuan HU
1
;
Youping LIU
1
;
Shilin CHEN
1
;
Lin CHEN
1
Author Information
1. State Key Laboratory of Southwestern Chinese Medicine Resources，School of Pharmacy， Chengdu University of Traditional Chinese Medicine，Chengdu 611137，China
2. Sichuan Neo-green Pharmaceutical Technology Development Co. Ltd.，Pengzhou 611930， China
- Publication Type:Journal Article
- Keywords:
Haliotidis Concha;
Haliotis discus hannai;
standard decoction;
quantity-quality transfer;
specific chromatogram;
X-ray diffraction（XRD）;
X-ray fluorescence spectrometry（XRF）;
Fourier transform infrared spectrometry（FTIR）
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(13):206-214
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the quantity-quality transfer process of medicinal materials， decoction pieces and standard decoction of Haliotidis Concha（Haliotis discus hannai） by analyzing the physical phase and compositional changes， so as to provide references for the effective control of its quality. MethodsA total of 20 batches of Haliotidis Concha（H. discus hannai） from different habitats were collected and prepared into corresponding calcined products and standard decoction， and the content of CaCO3 of the three samples were determined and the extract yield and transfer rate of CaCO3 were calculated. The changes in elemental composition and their relative contents were investigated by X-ray fluorescence spectrometry（XRF）， X-ray diffraction（XRD） was used to study the changes in the phase compositions of the three samples and to establish their respective XRD specific chromatogram. Fourier transform infrared spectrometry（FTIR） was used to study the changes in the chemical composition and content changes of the three samples and to establish their respective FTIR specific chromatogram， while combining hierarchical cluster analysis（HCA）， principal component analysis（PCA） and orthogonal partial least squares-discriminant analysis（OPLS-DA） to find the common and differential characteristics， in order to explore the quantity-quality transfer relationship in the preparation process of standard decoction of Haliotidis Concha（H. discus hannai）. ResultsThe CaCO3 contents of the 20 batches of medicinal materials， decoction pieces and standard decoction of Haliotidis Concha（H. discus hannai） were 93.87%-98.95%， 96.02%-99.97% and 38.29%-51.96%， respectively， and the extract yield of standard decoction was 1.71%-2.37%， and the CaCO3 transfer rate of decoction pieces-standard decoction was 0.68%-1.27%. XRF results showed that the elemental species and their relative contents contained in Haliotidis Concha and its calcined products had a high degree of similarity， and although there was no obvious difference in the elemental species contained in decoction pieces and standard decoction， the difference in the relative contents was obvious， which was mainly reflected in the decrease of the relative content of element Ca and the increase of the relative content of element Na. XRD results showed that Haliotidis Concha mainly contained CaCO3 of aragonite and calcite， while calcined Haliotidis Concha only contained CaCO3 of calcite， and standard decoction mainly contained CaCO3 of calcite and Na2CO3 of natrite. FTIR results showed that there were internal vibrations of O-H， C-H， C=O， HCO3- and CO32- groups in Haliotidis Concha， while O-H， HCO3- and CO32- groups existed in the calcined products and standard decoction. ConclusionThe changes of Haliotidis Concha and calcined Haliotidis Concha are mainly the increase of CaCO3 content， the transformation of CaCO3 aragonite crystal form to calcite crystal form and the absence of organic components after calcination， and the changes of calcined products and standard decoction are mainly the decrease of CaCO3 content and the increase of Na2CO3 relative content. The method established in the study is applicable to the quality control of the shellfish medicines-decoction pieces- standard decoction， which provides a new idea for the study of quality control of dispensing granules of shellfish medicines.
