Mechanisms of Traditional Chinese Medicine in Prevention and Treatment of Stroke by Regulating Ferroptosis： A Review
10.13422/j.cnki.syfjx.20250401
- VernacularTitle:中医药调控铁死亡防治脑卒中的作用机制
- Author:
Mingyan WEI
1
;
Shanze LI
1
;
Rui HAN
1
;
Qingbi LI
1
;
Xingyi SUN
1
;
Han ZHANG
1
;
Lin LI
1
Author Information
1. State Key Laboratory of Component-based Chinese Medicine， Tianjin University of Traditional Chinese Medicine，Tianjin 301617，China
- Publication Type:Journal Article
- Keywords:
stroke;
Chinese medicine compound formulas;
monomers;
ferroptosis;
neuroprotective mechanisms
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(12):313-321
- CountryChina
- Language:Chinese
-
Abstract:
Stroke is one of the leading causes of death and disability worldwide， ranking as the second leading cause of mortality globally and the primary cause of adult disability. Its pathological process involves complex cascade mechanisms， with high incidence and disability rates， posing a major threat to human health. According to statistics from the World Health Organization， more than 13 million new cases of stroke occur globally each year， resulting in direct medical costs and socioeconomic burdens amounting to hundreds of billions of dollars. In recent years， breakthroughs in the study of programmed cell death mechanisms have provided new insights into stroke treatment. Among them， ferroptosis， a novel form of cell death driven by iron-dependent lipid peroxidation， has attracted widespread attention in the pathological process of stroke. Ferroptosis is closely associated with iron metabolism disorders， oxidative stress， and lipid peroxidation， and exhibits unique regulatory effects in key pathological processes of stroke， such as ischemia-reperfusion injury， disruption of the blood-brain barrier， and neuronal apoptosis. It plays an important role in post-stroke neurological damage. Chinese medicine， as an essential component of traditional Chinese medicine （TCM）， has demonstrated advantages in modulating ferroptosis and exerting neuroprotective effects. This review systematically summarizes current research on the neuroprotective mechanisms of Chinese medicine compound formulas and monomers through the regulation of ferroptosis pathways in post-stroke conditions， aiming to provide a basis for optimizing clinical treatment strategies and exploring new therapeutic approaches， and to offer new strategies and approaches for stroke treatment.
