Clinical Research on Guizhi Fulingwan in Treatment of Ovarian Cancer： A Review
10.13422/j.cnki.syfjx.20251594
- VernacularTitle:桂枝茯苓丸治疗卵巢癌临床研究的前沿进展
- Author:
Muxin GUAN
1
;
Jiaxing FENG
2
;
Mengyi ZHU
1
;
Yu WANG
2
;
Xiaoke WU
2
Author Information
1. Heilongjiang University of Chinese Medicine，Harbin 150400，China
2. The First Affiliated Hospital of Heilongjiang University of Chinese Medicine，Harbin 150400，China
- Publication Type:Journal Article
- Keywords:
Guizhi Fulingwan;
ovarian cancer;
clinical application;
review
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(12):296-303
- CountryChina
- Language:Chinese
-
Abstract:
Ovarian cancer （OC） is a common gynecological malignant tumor in clinical practice. In the early stage，it is often asymptomatic，while in the late stage，it mainly presents with non-specific symptoms such as abdominal distension，poor appetite，and dull abdominal pain. Some patients may also have cachexia such as weight loss and anemia. Early diagnosis is difficult，and the mortality rate ranks first among gynecological malignant tumors，making OC a major challenge in clinical treatment. The classic Chinese medicine formula Guizhi Fulingwan comes from the Jingui Yaolue and has the effects of promoting blood circulation，removing blood stasis，and reducing abdominal lumps. In recent years，it has been widely used to treat OC with good results. This article summarized the clinical application of Guizhi Fulingwan in the treatment of OC from two aspects：The analysis of its basic prescriptions and clinical research. In terms of basic prescriptions，the formula has the ability to promote blood circulation，remove blood stasis，and reduce abdominal lumps. It can exert therapeutic effects considering both water and blood aspects and reduce abdominal lumps， with characteristics of simultaneous Yang warming and heat clearing and parallel supplementation and elimination. Through the methods of "circulation" and "supplementation"， it strengthens the body，dispels evil，and eliminates underlying symptoms. In clinical studies，Guizhi Fulingwan can be applied to various stages of patients with OC，which not only promotes the recovery of the body after OC surgery but also can be combined with chemotherapy and immunotherapy to synergistically treat advanced OC and enhance treatment efficacy. In addition，the formula can also alleviate various adverse reactions caused by chemotherapy，with high safety，improve patients' quality of life，prolong survival，and optimize tumor control effects. Based on the above analysis，this article elaborated on the current clinical research status of Guizhi Fulingwan combined with Western medicine in the treatment of OC and proposed suggestions and improvements to address the shortcomings in current clinical research，so as to provide reference for the clinical application of this formula in the treatment of OC and the construction of a combined traditional Chinese and Western medicine treatment model.
