Traditional Chinese Medicine in Regulating Crown-like Structures for Treatment of Obese PCOS： A Review
10.13422/j.cnki.syfjx.20250795
- VernacularTitle:中医药调节冠状结构治疗肥胖型多囊卵巢综合征的研究进展
- Author:
Wenyan TU
1
;
Liqun YE
1
;
Muyang LI
1
;
Yihong YIN
1
;
Ying SHEN
1
;
Qidi LIN
1
Author Information
1. Ningbo Municipal Hospital of Traditional Chinese Medicine， Affiliated Hospital Zhejiang Chinese Medical University Ningbo 315010，China
- Publication Type:Journal Article
- Keywords:
polycystic ovary syndrome;
obesity;
crown-like structure;
adipose tissue inflammation;
traditional Chinese medicine;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(13):296-307
- CountryChina
- Language:Chinese
-
Abstract:
Polycystic ovary syndrome （PCOS）， a common reproductive endocrine disorder in women， is one of the leading causes of ovulatory infertility in women of reproductive age. Due to its heterogeneous etiology， complex symptoms， and challenging treatment， PCOS has become a focal point of research in gynecological and reproductive medicine globally. The pathogenesis of PCOS is complex and may involve regulatory mechanisms such as inflammatory responses， oxidative stress， and cellular autophagy. Crown-like structures （CLSs） refer to pro-inflammatory microenvironments formed by macrophages engulfing adipocytes. The inflammatory disorders induced by CLSs are one of the key factors contributing to the development of PCOS and its complications. Current studies have indicated that the obese status in PCOS accelerates the formation of CLSs， and the density of CLSs can predict the progression of metabolic disorders and influence the outcomes of various metabolic diseases. Traditional Chinese Medicine （TCM） offers the unique advantages of a holistic view， four diagnostic methods， and syndrome differentiation and treatment to ameliorate the symptoms and signs of PCOS through multiple levels， pathways， and targets. Although studies on the mechanisms of metabolic diseases and CLS formation have been reported in China and abroad， there is still a lack of literature on the correlation between CLSs and PCOS， as well as reviews on TCM interventions targeting CLSs for treating this disease. Therefore， this paper summarized the correlation between obese PCOS and CLSs and reviewed recent studies on TCM interventions based on CLS formation （adipose tissue-macrophage inflammatory crosstalk） in the treatment of obese PCOS， aiming to provide new research perspectives for the prevention and treatment of PCOS using TCM.
