Analysis of Clinical Consistency of Animal Models of Attention Deficit Hyperactivity Disorder Based on Characteristics of Clinical Diseases and Syndromes in Traditional Chinese and Western Medicine
10.13422/j.cnki.syfjx.20241317
- VernacularTitle:基于中西医临床病证特点的注意缺陷多动障碍动物模型的临床吻合度分析
- Author:
Xinyue XIE
1
;
Xiaomian LIU
2
;
Ming LI
3
;
Mengfei WANG
1
;
Rongyi ZHOU
1
Author Information
1. Pediatric Hospital，The First Affiliated Hospital of Henan University of Chinese Medicine， Zhengzhou 450000，China
2. School of Medicine，Henan University of Chinese Medicine，Zhengzhou 450046，China
3. School of Ethnology and Sociology，YunnanUniversity，Kunming 650091，China
- Publication Type:Journal Article
- Keywords:
attention deficit hyperactivity disorder;
characteristics of diseases and syndromes;
model evaluation;
integration of traditional Chinese medicine and western medicine;
behavioral study
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(13):270-278
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveBased on a new method for animal model evaluation， this study aims to analyze the characteristics of diseases and syndromes of existing animal models of attention deficit hyperactivity disorder （ADHD） from both traditional Chinese medicine （TCM） and western medical perspectives and propose suggestions for improvement. MethodsA systematic search of the China National Knowledge Infrastructure （CNKI） and PubMed was conducted for literature on ADHD animal models. According to TCM and western medical diagnostic criteria， core and accompanying symptoms of the models were assigned with scores to comprehensively evaluate the clinical consistency. ResultsThe selection of experimental animals for ADHD models primarily involved rodents， with modeling methods including genetic， chemical induction， and environmental induction. The average consistency of clinical diseases and syndromes with TCM and western medicine was 45.19% and 49.42%， respectively. The spontaneously hypertensive （SHR） rats and nicotine/smoking models had the highest consistency with TCM， while the social isolation models had the highest consistency with western medicine. Most models were guided by western medicine theories， which can meet the surface validity and structural validity requirements of western medicine but lacked precise differentiation of TCM syndromes. ConclusionExisting ADHD animal models primarily focus on a single genotype or environmental factor， lacking comprehensive consideration of multigenic interactions and environmental factors. Moreover， the selection of model evaluation indicators is relatively singular， primarily focusing on "disease" indicators， while TCM "syndrome" indicators have not been fully considered. It is recommended to introduce a "formula-to-syndrome" approach in the preparation of TCM models for ADHD and establish and improve an evaluation system of animal models combining diseases and syndromes， so as to provide a solid foundation for future experimental research.
