Chronic kidney disease and serum NT-proBNP level
- VernacularTitle:Бөөрний архаг өвчин ба сийвэн дэх NT-proBNP агууламж
- Author:
Sodgerel B
1
;
Anudari I
1
;
Buyandelger J
1
;
Pilmaa Yo
1
;
Gantogtokh D
1
;
Yesukhei E
1
;
Bilguun E
1
;
Nyam-Erdene N
1
;
Yundendash D
1
;
Munkhbayar S
1
;
Bolormaa Do
2
;
Sarangerel Ga
2
;
Munkhzul D
2
;
Batbold B
1
;
Sodnomtsogt L
3
Author Information
1. Institute of Medical Sciences of Mongolia
2. Kidney and Endocrinology Department, The Third State Hospital
3. Institute of Neuroscience and Psychology
- Publication Type:Journal Article
- Keywords:
heart failure;
hemodialysis;
left ventricular ejection fraction;
renal dysfunction;
serum natriuretic peptide
- From:Mongolian Medical Sciences
2024;210(4):9-17
- CountryMongolia
- Language:Mongolian
-
Abstract:
Background:Serum natriuretic peptide (NT-proBNP) is a critical biomarker for diagnosing left ventricular
dysfunction. Heart failure is the leading cause of mortality in chronic kidney disease (CKD),
emphasizing the need for its early detection and prognosis.
Objective:This study aimed to determine the serum NT-proBNP levels in participants with CKD and
establish a cut-off value for predicting heart failure.
Methods:A descriptive cross-sectional study was conducted from April 1 to July 1,2024. This study
received approval from the Ethics Committee of the Institute of Medical Sciences (Approval
No.24/01). A total of 117 CKD patients hospitalized in the Nephrology and Endocrinology
Department of the third state hospital were enrolled based on predefined inclusion and
exclusion criteria. Data were collected using questionnaires, laboratory and heart ultrasound
test results. Serum NT-proBNP levels were measured using a rapid immunofluorescence
quantitative analyzer. Data were analyzed with SPSS 26.0.
Results:The mean age of the 117 participants was 57.9 ± 14.7 years, with 51.3% being male. The
mean serum NT-proBNP level was 7686 ± 12149 pg/mL. Statistically significant differences
were observed in serum creatinine, sodium, calcium, CKD stage, and arterial hypertension
between genders (p<0.05). NT-proBNP levels in hemodialysis patients differed significantly
between heart failure and non-heart failure groups (p<0.05). Significant differences were
also found in hemoglobin, serum albumin, NT-proBNP levels, and CKD stages (p<0.05).
NT-proBNP correlated significantly with risk factors such as hemodialysis, diabetes, and decreased systolic blood pressure (p<0.0001). A weak inverse relationship was noted
between systolic blood pressure and NT-proBNP (R² = 0.16). The NT-proBNP cut-off value
for predicting heart failure was 3027 pg/mL, with an AUC of 61.7% (sensitivity: 74.5%,
specificity: 55%).
Conclusion:Serum NT-proBNP levels are elevated in CKD patients regardless of heart
failure. The established cut-off value for NT-proBNP in CKD patients to detect heart failure
was 3027 pg/mL, with moderate diagnostic utility (AUC = 61.7%).
- Full text:2025060517111185376MmS-2024-210(4)-9-17.pdf
