Some results of the standardization of Zidraga-6 capsule Introduction
- VernacularTitle:Зидрага-6 капсултай эмийн стандартчиллын зарим үзүүлэлтийг тодорхойлсон дүн
- Author:
Myadagbadam U
1
;
Chimedragchaa Ch
1
;
Anu A
1
;
Dejidmaa B
1
;
Erdenechimeg Ch
1
Author Information
1. Institute of Traditional Medicine and Technology
- Publication Type:Journal Article
- Keywords:
oleanolic acid;
P-Methoxycinnamate;
Capsaicin;
Qualitative studies;
Triterpene saponin
- From:Mongolian Medical Sciences
2024;209(3):47-55
- CountryMongolia
- Language:Mongolian
-
Abstract:
The “Zidraga-6” prescription, which is widely used in traditional medicine, was
selected and technologically developed, and formed into capsule medicine. Zidraga-6
capsule was prepared using six different herbal Capsicum annuum L. Holarrhena
antidysenterica Wall ex, Atragene sibirica L, Embelia ribes Burm, Terminalia chebula
Retz, and Kaempferia galanga L.
Goal:This study was conducted to standardize and determine the safety and quality
parameters of the Zidraga-6 capsule.
Materials and Methods:Quality (moisture, total ash) and safety parameters were determined by Mongolian
National First Pharmacopoeia methods. The content of the main biologically active
compounds in the Zidraga-6 capsule was identified using TLC. In addition, the
content of biologically active compounds is determined by UV spectrophotometer
methods. The results were processed using basic biostatistical methods, calculating
the arithmetic mean (M), standard deviation (δ), and standard error (m) using the
SPSS 20.0 program. The ethical approval for the study was obtained by a decision
of the Ministry of Health - Medical Ethics Review Committee on research on May 23,
2023 (23/029).
Results:The presence of p-methoxycinnamate, gallic acid, oleanolic acid, and capsaicin in the
Zidraga-6 capsule drug was detected by the TLC method, and their Rf values were
0.26, 0.24, 0.82, and 0.45, respectively. The average weight of Zidraga-6 capsules
was 0.4±0.019 g, moisture was 9.63±0.09%, disintegration was 6.48±0.37 minutes,
dissolution was 94.68±2.85%. The content of methods biologically active compounds
in the Zidarga-6 capsule was determined total triterpene saponins as 1.89±0.19% by
UV spectrophotometric methods.
Conclusion:We determined quality and safety parameters of the Zidraga-6 capsule were defined
and the Mongolian National Pharmacopoeia monograph’s draft for the Zidraga-6
capsule was developed.
- Full text:2025060516333578815MMS-2024-209(3)-47-55.pdf
