The evaluation of the WOI by using ER, PR, Ki67 proliferation index in thin endometrium patients
- VernacularTitle: Умайн салстын нимгэрэлийн үед өндгөвчний дааврын рецептор болон Ki67 пролиферацийн индексийг тодорхойлсон нь
- Author:
Narangerel N
1
;
Munkhtsetseg D
1
;
Yanjinsuren D
2
;
Bum Chae Choi
3
Author Information
1. Department of OBG, School of Medicine, MNUMS
2. Ach Medical University
3. CL Fertility Clinic Mongolia
- Publication Type:Journal Article
- Keywords:
infertility;
thin endometrium;
PRP;
windows of implantation;
estrogen;
progesterone;
Ki67 proliferation index
- From:Mongolian Medical Sciences
2024;207(1):15-19
- CountryMongolia
- Language:Mongolian
-
Abstract:
Introduction:The endometrium is to receive the embryo and endometrial receptivity predicts successful implantation
during window of implantation (WOI). During implantation and pregnancy ER,PR,Ki67 significant
controllers of endometrial decidualization. The PRP is promoting cell proliferation neoangiogenesis and
anti-inflammatory effects, facilitating successful implantation indicating the safe as well as a potential
therapeutic response to its application in patients with RIF with thin endometrium.
Goal:Our aim was to further elucidate the role of WOI as a diagnostic and prognostic tool to RIF with thin
endometrium in the fertility field. Also the importance of PRP treatment.
Materials and Methods:A prospective study was done of 72 infertile thin endometrium women with history of recurrent implantation failure (RIF). All women underwent hysteroscopy followed by endometrial sampling for histological examination. WOI was studied using the immu-nohistochemicall method of determining Ki67, ER, PR, 6 tissue preparations were excluded due to an unsatisfactory amount of tissue. Therefore, data about tissue specimens from 66 patients were included in statistical analysis. Differences in implantation rate between 2 groups were evaluated using the chi square test. Endometrial thickness was calculated by a repeated measures ANOVA test with greenhouse method. This study received approval from the Ethics
Committee under the reference number 2021/3-202109 and conducted at the CL fertility clinic.
Results:In this study, out of 72 cases, 6 were removed, 42 were synechiae, 24 were polyp. Ki67, ER, PR
immunohistochemistry expression was found in 66 and endometrial delay was diagnosed 73,6% (Figure
1). Endometrial thickness was significantly increased with the PRP group. After adjusting the WOI,
significant increase in implantation 58% and clinic pregnancy 38% (Figure 2).
Conclusion:Adjusting WOI, receiving PRP treatment in infertile women with thin endometrium significantly associated
with implantation rate and pregnancy rate prognostic indicators including Ki67 proliferation index,
ER,PR.
- Full text:2025060517425697197MMS-2024-207(1)-15-19.pdf
