Biological and clinical aspects of S100 Proteins
- VernacularTitle:S100 уургийн биологи, эмнэлзүйн ач холбогдол
- Author:
Mungun B
1
,
2
;
Ganbold L
1
;
Munkhtsetseg G
3
Author Information
1. Department of Critical Care Medicine and Anesthesiology, School of Medicine, MNUMS
2. National Center for Maternal and Child Health
3. Department of Biochemistry, School of Biomedicine, MNUMS
- Publication Type:Review
- Keywords:
S100 proteins;
brain injury;
cancer marker;
human
- From:Mongolian Medical Sciences
2023;205(4):67-74
- CountryMongolia
- Language:Mongolian
-
Abstract:
S100 proteins regulate intracellular processes such as cell growth and motility, cell cycle regulation,
transcription and differentiation. S100 proteins represent the largest subgroup in the EF-hand Ca2+
binding protein family. The S100 protein family consists of 24 members functionally distributed into
three main subgroups: those that only exert intracellular regulatory effects, those with intracellular and
extracellular functions and those which mainly exert extracellular regulatory effects.
Within cells, S100 proteins are involved in aspects of regulation of proliferation, differentiation, apoptosis,
Ca2+ homeostasis, energy metabolism, inflammation and migration/invasion through interactions with
a variety of target proteins including enzymes, cytoskeletal subunits, receptors, transcription factors
and nucleic acids. S100 proteins have received increasing attention due to their close association with
several human diseases including cardiomyopathy, neurodegenerative disorders and cancer. They
have also been proven to be valuable in the diagnostic of these diseases, as predictive markers of
improving clinical management, outcome and survival of patients and are considered having a potential
as drug targets to improve therapies.
- Full text:2025060517460853569MMS-2023-205(4)-67-74.pdf
