comparison between pulmonary function with clinical features in patients with systemic sclerosis-related interstitial lung disease
- VernacularTitle:Уушгины завсрын эдийн эмгэг бүхий тогтолцооны хатууралтай өвчтөнүүдэд уушгины агааржилтын үйл ажиллагааг эмнэлзүйн зарим үзүүлэлттэй харьцуулсан судалгаа
- Author:
Allabyergyen M
1
;
Agidulam Z
1
;
Maral B
1
;
Altanzul B
2
;
Ichinnorov D
3
;
Tsolmon D
2
Author Information
1. Postgraduate training institute, MNUMS
2. Department of Rheumatology, School of Medicine, MNUMS
3. Department of Pulmonology and Allergology, School of Medicine, MNUMS
- Publication Type:Journal Article
- Keywords:
Spirometry;
Pulmonary fibrosis;
Syndrome;
Forced vital capacity;
Pulmonary function
- From:
Mongolian Journal of Health Sciences
2025;86(2):160-164
- CountryMongolia
- Language:Mongolian
-
Abstract:
Background:Systemic sclerosis-related interstitial lung disease (ILD) is a major cause of mortality among patients with
systemic sclerosis. During this disease, when the forced vital capacity (FVC) is <50% on spirometry, the prognosis is
considered poor. Although early changes in systemic sclerosis-related ILD can be identified by chest computed tomography
(CT), evaluating the spirometry test is essential for monitoring further follow-up and assessing treatment outcomes.
This study aimed to highlight the importance of considering the role of the spirometry test among patients with systemic
sclerosis.
Materials and Methods:We conducted this study using a cross-sectional research design based at a single-center hospital.
The study included 40 patients diagnosed with systemic sclerosis who were attending the rheumatology outpatient
clinic at the Mongolia-Japan Hospital. The inclusion criteria were patients diagnosed with systemic sclerosis who had
undergone chest imaging (chest x-ray, chest CT scan) and spirometry tests.
Results:In our study, in 62.5% of patients diagnosed with systemic sclerosis, a chest CT scan revealed abnormalities indicative
of SSc-ILD. There were statistically significant differences (p<0.05) in certain parameters of spirometry between
the two groups (normal chest CT, abnormal chest CT). The group with abnormal chest CT had a higher usage of mycophenolate
mofetil (p<0.05). A negative correlation was found between changes on chest CT scan and FVC (r= -.453, p<0.05).
However, no statistically significant correlation was observed between FVC and disease duration or comorbidities.
Conclusion:Using spirometry to assess pulmonary function in patients with systemic sclerosis-related interstitial lung
disease may be an appropriate method for evaluating the progression of the disease and detecting complications.
- Full text:2025052913334362024160-164.pdf
