Acute and chronic toxicity effects of traditional medicine Shimshin-6
- VernacularTitle:Уламжлалт Шимшин-6 эмийн хурц болон архагдуу хорон чанарын судалгааны үр дүн
- Author:
Nomin-Erdene J
1
,
2
;
Dejidmaa B
3
;
Erdenechimeg Ch
3
;
Munkhtsetseg D
4
;
Chimedragchaa Ch
3
Author Information
1. Darkhan-Uul Medical School, MNUMS
2. International School of Mongolian Medicine, MNUMS
3. Institute of Traditional Medicine and Technology
4. Department of Obstetrics and Gynecology, School of Medicine, MNUMS
- Publication Type:Journal Article
- Keywords:
Involution;
Postpartum;
lohia;
Traditional medicine
- From:
Mongolian Journal of Health Sciences
2025;86(2):143-148
- CountryMongolia
- Language:Mongolian
-
Abstract:
Background:In traditional medicine, the Shimshin-6 formulation, which consists of Rheum undulatum L., Hippophae
rhamnoides L., Zingiber officinalie Roscoe, Saussurea Lappa C.B.Clark, Sal ammoniacum, Tronae veneni, is recommended
for women experiencing menstrual retention disorders. In recent years, Shimshin-6 has been widely used to
promote postpartum uterine involution for women and our study aimed to evaluate and determine the acute and chronic
toxicity effects of Shimshin-6.
Aim:To evaluate and substantiate the acute and chronic toxicity effects of Shimshin-6.
Materials and Methods:The acute toxicity of Shimshin-6 was evaluated using the rapid method described by V.B. Prozorovsky
(1978) by administering intraperitoneal injections of the medicinal extract in white mice to determine the lethal
dose. The active dose was determined following the methodology of I.P. Zapadnyuk (1983). Chronic toxicity was evaluated
in Wistar rats according to the OECD 407 (2008) guidelines. The test animals were administered Shimshin-6 in tablet
form (90 mg/kg and 180 mg/kg) and decoction form (tang) (162 mg/kg) daily for 60 days. At the end of the experiment,
biochemical and complete blood analyses were conducted, along with histopathological examination of major organs.
The study was conducted with ethical approval granted by the Ethics Committee of the Mongolian National University of
Medical Sciences (MNUMS) on October 25, 2024.
Results:The LD50 for Shimshin-6 tablets was 4.47 (3.39–5.1) g/kg, indicating low acute toxicity based on the K.K.
Sidorov classification. The LD50 for the decoction form was 8.1 (7.1–9.4) g/kg, suggesting it is non-toxic. Regarding
chronic toxicity, platelet count was significantly reduced compared to the healthy control group: Shimshin-6 tablet group:
46% reduction at 90 mg/kg and 29.7% reduction at 180 mg/kg. Shimshin-6 decoction group: 60.5% reduction at 162 mg/
kg. Additionally, hemoglobin levels in the decoction group (162 mg/kg) decreased by 15.7% (p<0.05). Biochemical analysis
showed a 36.3% reduction in total cholesterol (LDL-C) levels in the tablet group (180 mg/kg) and decoction group
(162 mg/kg) compared to the control (p<0.05).
Conclusion:Shimshin-6 tablets showed low acute toxicity in experimental mice. However, long-term administration may
lead to a reduction in platelet count.
- Full text:2025052913153506034143-148.pdf
