The toxicity effects of silybum marianum peptides
- VernacularTitle:Толбот арзаахай ургамлын пептидын хорон чанарын судалгааны дүн
- Author:
Ananda
1
,
2
;
Su Xiulan
2
;
Oyungerel Sh
1
;
Enkhtungalag S
1
;
Tsend-Ayush D
1
,
3
;
Saikhanaa N
3
Author Information
1. Department of Traditional Prescriptionology, International School of Mongolian Medicine, MNUMS
2. Inner Mongolia Medical University, IMMU
3. Institute of Mongolian Traditional Medicine, MNUMS
- Publication Type:Journal Article
- Keywords:
Silybum marianum peptide;
ALT enzyme activity;
ALI;
Hepatoprotection;
Toxicity
- From:
Mongolian Journal of Health Sciences
2025;86(2):125-130
- CountryMongolia
- Language:Mongolian
-
Abstract:
Background:Silybum marianum, as well as known milk thistle, has long been recognized for its hepatoprotective effects,
primarily attributed to its active flavonolignan complex, silymarin (an extract from water hyacinth fruit). While the
pharmacological effects of silymarin have been studied, research on bioactive peptides derived from Silybum marianum
remains limited.
Aim:To evaluate the toxicity effects of silybum marianum peptides
Marerials and Method:This study aimed to evaluate the potential toxicity of Silybum marianum peptide in mice through
a 14-day oral administration experiment. Twenty adult male C57BL/6 mice were divided into two groups: the experimental
group received 200 mg/kg of Silybum marianum peptide daily, while the control group received an equivalent volume
of saline solution. Physiological and biochemical parameters, including body weight, fasting blood glucose levels, liver
and spleen wet weights, as well as alanine aminotransferase (ALT) enzyme activity, were assessed to determine potential
toxic effects. This exploration aims to shed light on the toxicological effects of silybum marianum peptide in mice, providing
insights into its potential benefits and challenges.
Results:Results indicated no significant differences between the experimental and control groups in terms of body
weight, blood glucose levels, or major organ wet weights. Additionally, ALT enzyme activity remained unaffected, suggesting
no detectable liver toxicity. Throughout the study, no abnormal behaviors, physical changes, or mortality were
observed in the test subjects. Mice in both the silybum marianum peptide and control groups exhibited shiny and soft
fur, normal activity, and regular food consumption. These findings indicate that Silybum marianum peptide exhibits good
safety and low biological toxicity under the tested conditions, supporting its potential use as a safe dietary supplement or
therapeutic agent.
Conclusion:At the designated dosage, silybum marianum peptide demonstrated good safety and low biological toxicity.
- Full text:2025052912560675827125-130.pdf
