Incidence of Thrombocytopenia and Mortality Risk Among Patients in the Neonatal Intensive Care Unit
- VernacularTitle:Нярайн эрчимт эмчилгээний тасагт хэвтэн эмчлүүлэгчдийн дундах тромбоцитопенийн тохиолдлын тоо, нас баралтын эрсдэлийг судалсан нь
- Author:
Ulziibayar Ts
1
;
Gerelmaa Z
1
Author Information
1. Department of Pediadrics, School of Medicine, MNUMS
- Publication Type:Journal Article
- Keywords:
Thrombocytopenia;
Mortality;
Neonatal Intensive Care Unit (NICU)
- From:
Mongolian Journal of Health Sciences
2025;86(2):111-115
- CountryMongolia
- Language:Mongolian
-
Abstract:
Background:Thrombocytopenia is more commonly observed in neonates compared to other age groups, occurring in
1-5% of healthy newborns. However, the incidence of thrombocytopenia is significantly higher (22%-35%) in sick neonates
admitted to the Neonatal Intensive Care Unit (NICU), and numerous researchers have noted that severe thrombocytopenia
contributes to neonatal mortality. However, the incidence of thrombocytopenia and mortality risk among patients
in the NICU in our country has not yet been studied, which provided the rationale for our research.
Aim:To investigate and determine the incidence of thrombocytopenia and the risk of mortality in neonates treated in the
intensive care unit.
Materials and Methods:Data were collected from the medical histories of infants hospitalized in the Neonatal Intensive
Care Unit of the National Center for Maternal and Child Health in 2017-2019, and statistical processing was performed
using the STATA 16 program.
Results:Of all infants in our study, 56.53% (658) were boys and 43.47% (506) were girls. According to the gestational
age of newborns, 34.19% (398) were full-term (>37 weeks), 61% (710) were preterm (28-36 weeks), and 4.81% (56) were
extremely preterm (<28 weeks). According to birth weight, 33.65% (386) had low birth weight (2500g-1500g), 20.05%
(230) had very low birth weight (1500g-1000g), and 8.81% (101) had extremely low birth weight (<1000g).
Among the surveyed newborns, 534 (45.88%) had thrombocytopenia, and the number was 51.55% (200/388) in 2017,
46.15% (162/351) in 2018, and 40.47% (172/425) in 2019. The mean platelet count of newborns with thrombocytopenia
was 50.21±43.23. Early (age <72 hours) 23.41% (125), late (age ≥72 hours) 76.59% (409), light platelet count
(100-150x109/l) 17.42% (93), medium (50) -99x109/l) was 25.28% (135) and severe (<50x109/l) was 57.3% (306). The
duration of thrombocytopenia in these infants was 13.68±10.33 days, and 72.65% (388) of them had thrombocytopenia,
27.15% (145) died without thrombocytopenia, and 0.18% (1) had autoimmune thrombocytopenia was under medical
supervision and was discharged from the hospital. A total of 20.5% (239) of the neonates included in the study died, and
among them, 76.15% (182) had thrombocytopenia, which showed a statistically significant difference when compared
between the deceased and surviving groups (p<0.001). To determine whether neonatal thrombocytopenia is a risk factor
for mortality, a univariate logistic regression analysis was performed, showing that thrombocytopenia increases the risk of
mortality with an OR of 5.19 (p<0.001, 95% CI: 3.75-7.19). A multivariate logistic regression analysis further confirmed
this association, with an OR of 2.46 (p<0.001, 95% CI: 1.65-3.68), indicating that neonatal thrombocytopenia significantly
increases the risk of mortality.
Conclusion:Thrombocytopenia is commonly observed in neonates treated in the neonatal intensive care unit. Neonatal
thrombocytopenia increases the risk of neonatal mortality.
- Full text:202505291237566638111-115.pdf
