The cell protective effect of licorice and elecampane plant extracts from hydrogen peroxide-induced cytotoxicity
- VernacularTitle:Чихэр өвс ба өндөр зоосон цэцэг ургамлын хандны h2 o2-ийн эс хордуулалтанд үзүүлсэн эс хамгаалах нөлөөг тодорхойлсон дүн
- Author:
Anand A
1
;
Ariunzaya M
2
;
Ariunzaya Lkh
3
;
Zolzaya B
4
;
Sarnai Ts
5
;
Ariunzaya B
2
Author Information
1. Department of Health Research, Graduate School, MNUMS
2. Department of Immunology, School of Bio-Medicine, MNUMS
3. School of Pharmacy, Graduate School MNUMS
4. Department of Molecular Biology and Genetics, School of Bio-Medicine, MNUMS
5. Graduate School, MNUMS
- Publication Type:Journal Article
- From:
Diagnosis
2025;112(1):14-20
- CountryMongolia
- Language:Mongolian
-
Abstract:
The increasing prevalence of noncommunicable diseases (NCDs), driven by factors such as population growth, urbanization, and economic development, presents significant individuals,
families, challenges and to healthcare systems. These diseases are often linked to lifestyle choices, poor diet, and physical inactivity. As a result, there is growing interest in finding alternatives to synthetic
drugs, particularly those derived from medicinal plants. Medicinal plants are known to contain bioactive compounds that offer therapeutic properties with fewer side effects compared to conventional
pharmaceuticals. This study explores the cytoprotective effects of Glycyrrhiza uralensis (licorice) and Inula helenium (elecampane) extracts against oxidative stress induced by hydrogen peroxide (H2O2) in RAW 264.7 macrophage-like cells.
The study found that both plant extracts were non-toxic at doses ranging from 1 to 25 µg/mL and promoted cell growth (p<0.01). The results suggest that these extracts support cell survival and exhibit
biological activity.
To assess the antioxidant effects, various concentrations of H2O2 (10–400 µM) were tested, and 200 µM was found to significantly reduce cell viability. Licorice and elecampane extracts (10 µg/mL and 25 µg/ mL, respectively) enhanced cell viability and reduced oxidative damage. Both extracts significantly reduced cell death compared to the H2O2-only group (p<0.01), highlighting their potent antioxidant properties.
Conclusion:Glycyrrhiza uralensis and Inula helenium extracts demonstrated strong cytoprotective and antioxidant effects, supporting their potential as natural therapeutics for oxidative stress-related conditions.
- Full text:202505280928340978Diagnosis-2025-112(1)-14-20.pdf
