Metabolic changes of overweight and obese adults
- VernacularTitle:Илүүдэл жин ба таргалалтын үеийн бодисын солилцооны өөрчлөлт
- Author:
Yumchinsuren Ts
1
,
2
;
Dolgion D
1
;
Ganchimeg D
1
;
Enkhmend Kh
1
;
Otgongerel N
1
;
Gantogtokh D
1
;
Amin-Erdene G
1
;
Bolor U
1
;
Tegshjargal S
1
;
Batbold B
1
;
Shiirevnyamba A
1
;
Tulgaa L
1
Author Information
1. Institute of Medical Sciences
2. Graduate School, Mongolian National University of Medical Sciences
- Publication Type:Journal Article
- Keywords:
metabolic dysfunction;
metabolic synd
- From:
Diagnosis
2024;111(4):97-104
- CountryMongolia
- Language:Mongolian
-
Abstract:
Introduction:The worldwide prevalence of obesity and its metabolic complications have increased substantially in recent decades. According to the World Health Organization (WHO) indicate that in 2016, over 1.9 billion
adults were overweight and, of these, over 650 million were obese. Obesity is a major risk factor for heart disease, type 2 diabetes, steatotic liver, chronic liver disease, stroke, and some cancers. The global prevalence of obesity and its associated comorbidities continue to increase on a pandemic scale.
Aim:To determine metabolic changes in overweight and obese adults and their related diseases based on some parameters of anthropometric and laboratory tests.
Materials and Methods:This study was conducted with a case-control design in 2023–2024. There were 150 participants in
the study, 50 in the control group with normal weight, 50 in the overweight (BMI<29.9kg/m2)
case group, and 50 in the obesity (BMI>30kg/m2) case group. Subjects of three groups were matched by age (±1) and sex. We estimated anthropometric parameters and biochemical
laboratory analysis including glucose, lipid, ferrum, and liver parameters. CBC All statistical analysis was performed using SPSS 23 software. Categorical variables were described by numbers and percentages, and the numerical variables were characterized by the median (min and max) for the normal distribution, and mean± standard deviation for the non-normal distribution. The statistical
tests utilized were the Chi-square, Fisher’s exact, student t-test, and Mann–Whitney tests. Ethical approval for the survey was obtained from the Medical Ethics Committee under the Ministry of Health Of Mongolia in January 2023.
Results:The participants' average age was 46.73±11.45, with 60% being women (90) and 40% being men (60). The prevalence of central obesity and fat % were 52.3% and 37.2%, respectively. Between study
groups, there were significant differences in fat% (p=0.004), central obesity (p<0.001), FBG (p=0.024), cholesterin (p=0.017), LDL (p=0.018), HDL (p=0.003), ferrum (p=0.010), АЛАТ (p=0.020), and GGT (p<0.001).
Conclusion:In overweight and obesity groups, the body fat, fasting blood glucose, cholesterol, LDL, and ALT levels are
increased. These changes often lead to conditions like type 2 diabetes, arterial hypertension, steatotic liver disease, and liver fibrosis. Therefore, it is important to develop plans for prevention, early detection,
public awareness, and intervention programs targeting obesity in the general population.
- Full text:2025052723210349174Diagnosis-2024-111(4)-97-104.pdf
