Investigation result of the esophageal biopsy by immunohistochemical assay
- VernacularTitle:Улаан хоолойн уян дурангийн амьд сорьцын шинжилгээг хистохимийн аргаар судалсан дүн
- Author:
Munguntsetseg S
1
;
Bayarmaa E
2
;
Adilzaya D
2
Author Information
1. Department of Pathology, EHEMUT
2. Department of Pathology, School of Bio Medicine, MNUMS
- Publication Type:Journal Article
- Keywords:
esophagus;
pathological feature;
special staining assay;
goblet cell (бортгон хучуур эд);
precancerous disorder;
Barret’s esophagus;
esophageal adenocarcinoma
- From:
Diagnosis
2024;111(4):59-63
- CountryMongolia
- Language:Mongolian
-
Abstract:
Background: According to the statistics, Gastrointestinal disorders (GIDs) are the second of the leading five diseases among Mongolians, with an estimated 20% of GIDs by pathological diagnosis in 2022.
Additionally, esophageal adenocarcinoma is ranked in the 4th of the 10 most common cancer. Esophageal adenocarcinoma and its predispositions, and pathological changes are mostly located lower part of esophagus. Barret’s esophagus (BE) is consequences of goblet cell replaces
the stratified squamous epithelium due to chronic gastroesophageal reflux disease. If BE transfers to the dysplasia, its probability of carcinogenesis is 30-125 times higher, and 0.8% of dysplastic patients
with BE diagnosed with esophageal adenocarcinoma.
Pathologists play a critical role in confirming the diagnosis of BE and BE-associated dysplasia. Goblet cells are almost always identifiable on routine hematoxylin and eosin-stained sections with Alcian blue (at pH 2.5).
Purpose:To diagnose the esophageal biopsies via pathological immunohistochemical assay.
Methods and materials:We investigated 130 biopsies in 2017-2019 years from NFCH, and 254 biopsies in SSCH.
Result:A total of 384 biopsies were collected from both national central hospitals and hematoxylin and eosin-stained results were Barret’s esophagus (50 biopsy or 13%), followed by dysplasia (66 or 17%), GERD
(55 or 14%), squamous cell carcinoma (49 or 13%), chronic erosive lesions (41 or 11%), chronic esophagitis (40 or 10%), polyp (19 or 5%), adenocarcinoma (15 or 4%), acute esophageal erosion (5 or 1%), hyperplastic polyp (36 or 9%), and were others (8 or 2%), respectively.
As a result of immunohistochemical re staining of 50 biopsies with BE, Alcian blue were 87,8% and PAS were 97,4%.
- Full text:2025052723084346120Diagnosis-2024-111(4)-59-63.pdf
