Significance of natriuretic peptides in chronic kidney disease
- VernacularTitle:Бөөрний архаг өвчний үед натриуретик пептидийн ач холбогдол
- Author:
Enkhtamir E
1
;
Enkhtuya J
1
;
Ariunbold J
1
;
Munkhzol M
1
;
Saruultushin A
1
;
Tsolmon U
1
Author Information
1. Mongolian National University of Medical Sciences
- Publication Type:Journal Article
- From:
Diagnosis
2024;111(4):37-41
- CountryMongolia
- Language:Mongolian
-
Abstract:
Background:Cardiovascular disease (CVD) is currently the leading cause of morbidity and mortality worldwide. CVD
risk increases significantly even in the early stages of chronic kidney disease (CKD) and CVD deaths account for more than half of all known causes of death in patients with end stage renal disease. Cardiovascular risk factors such as hypertension, anemia, hyperphosphatemia, volume overload and
uremic toxins usually occur when eGFR is below 60 ml/min/1.73m2, while the subclinical atherosclerosis starts to develop in early stages of CKD. Serum N-terminal pro B type netriuretic peptide (NT-proBNP)
is important for predicting subclinical heart failure in patients with CKD.
Methods:Plasma NT-proBNP concentrations were measured in 37 patients with CKD (mean age = 54 years, female
48.6%). Renal function was assessed by estimated glomerular filtration rate (eGFR; ml/min/1.73m2) and the subjects were classified into five stages of CKD. Pearson correlation analysis was used to analyze
he relationship between renal function and serum NT-proBNP levels.
Results:The mean serum NT-proBNP level was in CKD stage I ( <50pg/ml, p<0.0001), CKD stage II (64.86±21.79 pg/ml, p<0.0001), CKD stage III(119.56±158.1pg/ml, p<0.0001), CKD stage IV (5801.8±7213.7 pg/ml, p<0.0001), CKDstage V (6993.1±9029.9 pg/ml l, p<0.0001). Serum NT-proBNP level was inversely correlated significantly with eGFR (r = -0.464, р = 0.004).
Conclusion:Our findings indicate the circulating levels of NT-proBNP increased with deteriorating kidney function and these values were highest in patients with CKD IV and CKD V stages.
- Full text:2025052722511234882Diagnosis-2024-111(4)-37-41.pdf
