Assessment of renal dysfunction using the MDRD equation, conducting a study when using vancomycin
- VernacularTitle:MDRD тэгшитгэлээр бөөрний үйл ажиллагааны алдагдлыг үнэлэн ванкомицин эмийн хэрэглээтэй холбон судлах нь
- Author:
Gonchigsumlaa D
1
;
Tamiraa Ts
1
;
Tsetsegdulam B
2
;
Nandinbayar B
2
;
Khaliun N
3
Author Information
1. School of Health, Etugen University
2. School of Pharmacology, Etugen University
3. Pharmacology Department, School of Biomedicine, MNUMS
- Publication Type:Journal Article
- Keywords:
dose of vancomycin;
creatinine clearance;
age;
body weight
- From:
Diagnosis
2024;109(2):70-77
- CountryMongolia
- Language:Mongolian
-
Abstract:
A study by Marsot and other investigators (2012) determined that the dose of vancomycin in adults is directly dependent on parameters such as creatinine clearance and body weight, as well as the need for dose correction. We used the MDRD equation to determine renal dysfunction in 113 inpatients and found grade I in 50.5%, grade II in 14.4%, grade III in 10.8%, grade IV in 6.3%, and grade V in 18%. There is a statistically significant difference (p=0.045) in renal dysfunction depending on the diagnosis. The average daily dose of vancomycin was 2.5 g, the total daily dose was 8.5 g, the total dose was 20.5 g. The daily dose and total dose of vancomycin were inversely proportional to age (g = -0.256), the daily dose was directly related to excess weight body (g=0.226), and days of vancomycin use are statistically significant (p=0.001) depending on the diagnosis.
Conclusion:Comprehensive programs are required to improve the vancomycin use in the hospitals. Vancomycin use should be monitored due to its large-scale empiric use. The rate of improper use of vancomycin in the infection and intensive care unit services may be high, and pharmacists must take appropriate action to optimize the use of the drug.
- Full text:2025052722341174412Diagnosis-2024-109(2)-70-77.pdf
