Current basic concepts and future research directions for drug delivery to tumor tissues and cells
- VernacularTitle:Хавдрын эд, эсэд эмийн бодис хүргэх өнөөгийн суурь ойлголтууд, судалгааны цаашдын хандлага
- Author:
Altansukh Ts
1
;
Chimedlkham B
2
;
Tserendolgor B
2
Author Information
1. School of Biomedicine, MNUMS
2. Mongolian University of Pharmaceutical Sciences
- Publication Type:Review
- Keywords:
Pharmaceuticals;
Engineering;
Cancer;
Active targeting mechanism
- From:
Mongolian Journal of Health Sciences
2025;85(1):273-277
- CountryMongolia
- Language:Mongolian
-
Abstract:
Background: New cases of cancer and cancer-related deaths are high in Mongolia. Therefore, it is a priority to develop
anticancer drugs based on recent scientific achievements, successes, and major theoretical concepts. Pharmaceutical nanotechnology, including pharmaceutical engineering, is developing rapidly, and the problem of drug delivery to tumor-triggered organs, tissues, and cells has been studied at many levels. Drug delivery systems are divided into organic, inorganic,
and complex nanocarriers based on their physicochemical properties. The specificity of drug targeting to tumor-triggered
organs, tissues, and cells can be explained by passive and active targeting mechanisms. The passive delivery mechanism
of drugs to tissues and cells is related to the tumor microenvironment and vascularization, while the active delivery mechanism is related to the principle of binding to specific receptors on the surface of tumor-transformed cells and releasing
the drugs into the cell.
Conclusion: Extensive research in this area in Mongolia has many benefits for the development of anti-cancer drugs.
- Full text:2025052717375944911273-277.pdf
