Recurrence and prognosis of patients with tongue squamous cell carcinoma
- VernacularTitle:Хавтгай хучуур эсийн гаралтай хэлний хорт хавдраар өвчлөгсдийн хавдрын дахилт болон тавиланг судалсан нь
- Author:
Oyuntsetseg D
1
;
Munkhdul A
2
;
Batbayr B
1
;
Khentii L
1
;
Urjinlkham J
3
Author Information
1. Department of Maxilla-Facial Surgery, School of Dentistry, MNUMS
2. Department of Maxilla-Facial Surgery, School of Dentistry, Ach Medical University
3. Department of Operative Dentistry, School of Dentistry, MNUMS
- Publication Type:Journal Article
- Keywords:
Cell differentiation;
Survival rate;
TNM stage;
Metastasis
- From:
Mongolian Journal of Health Sciences
2025;85(1):179-184
- CountryMongolia
- Language:Mongolian
-
Abstract:
Background:Squamous cell carcinoma, which accounts for 90-95% of oral cancer, arises from the uncontrolled and
disordered growth of keratinocyte cells in the mucous of lip and oral cavity. It occupies 2-3% of all cancers and 38% of
head and neck cancers.
Aim:To study recurrence and prognosis of patients with tongue squamous cell carcinoma
Materials and Мethods:Our study, based on retrospective cohort method was conducted from medical reports of 207
patients who were diagnosed with squamous cell carcinoma of oral cancer and at the Department of Head and Neck
Surgery, Radio and Chemotherapy of the National Cancer Center of Mongolia between 2009-2019 years. All statistical
analysis were carried out using STATA version 15.0 and we performed survival analysis using Kaplan-Meier method. All
statistical tests were two sided, and P-values less than 0.05 were considered significant. The study was approved by the
Research Ethics Committee of the Mongolian National University of Medical Sciences on June 08, 2021 (№ 2021/3-07).
Results:A total of 207 oral cancer cases were registered during the study period. The most common site of oral cancer
was the tongue (47.3%, 98/207). Of these, cases 69.4% (68) presented in males and 30.6% (30) in females. At the time of
diagnosis, 77 patients (78.5%) were in late stage (III, IV) and 76 cases (77.6%) were well-differentiated. During the study
period, 20 patients (20.4%) experienced tongue cancer recurrence; female patients (18.8%, 3/20) had significantly less
chance of recurrence compared to men (81.2%, 17/20), (p=0.033). Patients over 61 years old had higher oral cancer recurrence than patients under 60 years, but there was no significant difference in age groups. 90.6% (18/20) of tongue cancer
recurrence had with lymph node metastasis; compared to patients without lymph node metastasis (9.4%, 2/20), tongue
cancer recurrence was significantly higher (p=0.025). And there was a statistical difference in tongue cancer recurrence
percentage among clinical stages (p=0.003). Thirteen (69.4%) patients diagnosed in stage IV had oral cancer recurrence.
Pathological grading, and tumor size did not significantly influence cancer recurrence.
Conclusion:1. The gender, advanced stage and lymph node metastasis of patients with tongue cancer were significantly associated
with the presence of tongue cancer recurrence. (p=0.033, p=0.025, p=0.003).
2. The 5-year survival rate for tongue cancer was the lowest among the oral cancer, which we consider to be due to
factors such as late-stage diagnosis, and anatomical characteristics of tongue.
- Full text:2025052716180540489179-184.pdf
