The results of research on the formulation of traditional medicine Gishuun-3 in the form of granules
- VernacularTitle:Уламжлалт Гишүүн-3 тан эмийн мөхлөг эмийн хэлбэрт оруулах судалгааны үр дүн
- Author:
Badamtsetseg T
1
;
Batnairamdal Ch
1
;
Jambaninj D
1
Author Information
1. Department of Traditional Prescription Medicine, ISMM, MNUMS
- Publication Type:Journal Article
- Keywords:
Granules;
Constipation;
Total polyphenols;
Gishuun-3
- From:
Mongolian Journal of Health Sciences
2025;85(1):164-167
- CountryMongolia
- Language:Mongolian
-
Abstract:
Background:Gishuun-3 medicine is widely used for mild laxative, reverse elimination of flatulence, constipation, and
amennorrhea. Therefore, the basis of our research work is to select the medicine Gishuun-3, keep the medicinal composition intact and make it in the form of granules for easier to consume.
Aim:To study the possibility of using the drug Gishuun-3, which has been widely used in traditional medicine, in the
form of granules.
Materials and Methods: “Gishuun-3” The composition of the drug contains Gishuun, Arur, and Khujir. The following
methods and techniques were used to conduct the study. These include:
The following methods and methodology were applied in the study:
Quality parameters of the granules were determined by Mongolian National First Pharmacopoeia. TLC was used to detect
some biologically active substances that are predominant|y present in the granules.Quantitative analysis of some biologically active substances that are predominantly present in the granules were determined by spectrophotometry.
Results: Gishuun-3 was weighed in an appropriate amount, and 6 types of granules were produced by the method of wet
granulation using glucose, lactose, sucrose, lemon juice, sodium carboxymethyl cellulose (NaCMC), and vanilla (sugar) as auxiliary fillers. The M6 type granules were selected for further research and the technological instructions were
developed. Gallic acid and polyphenols contained in Gishuun-3 granules were identified by thin-layer chromatography.
The amount of polyphenolic compounds mainly contained in the granules was determined by spectrophotometry using
Folin-Chikalto reagent. It was determined that the granules meet the requirements for determining the quality criteria
required for the formulation of the drug, and it was determined that Gishuun-3 granules can be formulated into the form
of granules. 0.202+0.002%.
Conclusions:1. Among the 6 types of granular drugs selected in the study, the M6 model granules containing Member-3 tang thick
extract, glucose, lactose, sucrose, lemon juice, sodium carboxymethyl cellulose (NaCMC), and vanilla (sugar) honey were determined to be the most suitable for further research because they met the technological parameters and
quality criteria of the granular drug, and a technological scheme for producing this granular drug was developed.
2. In determining some quality criteria of the extracted granular drug, the moisture content was 1.48±0.16%, the size of
small particles was 4.43±0.13%, and the dispersion or distribution was 2.0±0.11% minutes, which met the general
requirements for granular drugs.
3. The total polyphenolic compounds contained in Gishuun-3 granules were determined by spectrophotometry to be
converted to gallic acid and were 0.202±0.002%.
- Full text:2025052716021750160164-167.pdf
