Anti-fever effects of Lish-6 in animal model of fever
- VernacularTitle: Туршилтын амьтанд үүсгэсэн халууралтын эмгэг загварт Лиш-6 уламжлалт эмийн нөлөөг судалсан дүн
- Author:
Enkhtungalag S
1
,
2
;
Dejidmaa B
3
;
Tsend-Ayush D
4
;
Chimedragchaa Ch
3
;
Erdenechimeg Ch
3
Author Information
1. Department of Traditional Prescriptionology, International School of Mongolian Medicine, MNUMS
2. School of Medicine, MNU
3. Institute of Traditional Medicine and Technology
4. Innovation and Prescription Research Section, Institute of Mongolian traditional Medicine, MNUMS
- Publication Type:Journal Article
- Keywords:
Traditional drug;
Fever;
Rectal fever;
IL-1β;
PGE2;
IL-6 cytokines
- From:
Mongolian Journal of Health Sciences
2025;85(1):142-147
- CountryMongolia
- Language:Mongolian
-
Abstract:
Background:Lish-6 has been used for treatment pharyngitis, flu and throat disease. Lish-6 is composed from Eugenia
caryophylla. Thumb, Saussurea lappa C.B. Clark, Schizostachoum chinense. Rendle, Glycyrrhiza uralensis. Fisch, Gentiana algida Pall, Terminalia chebula. Retz. Anti-fever properties of these plants and their bio-active compounds have
extensively been studied.
Aim: To determine the anti-fever effects of Lish-6.
Marerials and Methods:Fever was induced by intravenous administration of lipopolysaccharide (LPS) at concentration
of 0.5 mg/kg. Lish-6 was given orally at concentration of 92 mg/kg, 1 and 6 hours after the LPS administration. Rectal
temperature wa measured 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 hours after the LPS administration. Paracetamoli was given orally
at concentration of 50 mg/kg. Blood levels of Prostaglandin E2
(PGE2) and interleukin-6 (IL-6) interleukin-1β (IL-1β)
were determined by enzyme linked immune sorbent assay using rat kits. Lung tissue was examined by histopathological
analysis.
Results:The body temperature of rats in the normal group was 35.0±1.10С, while in the control group, periodic fever was
caused by the effect of lipopolysaccharide (p=0.001). But in the Lish-6 drug group, rectal temperature decreased steadily
(p=0.05). In addition, the IL-1β cytokine in the normal group was 3.24±0.31 ng/L and increased by 60.5% in the control,
indicating the development of the pathological model, while this parameter decreased by 31% in the Lish-6 drug group
(p=0.05). IL-6 cytokine in the normal animals was 21.1±0.2 pg/L and increased by 19.04% in the control, indicating the
development of the pathological model, while this parameter decreased by 8.3% in the Lish-6 drug group (p =0.05). PGE2
in the normal group was 43.2±0.3 ng/L, and it increased by 62.7% in the control group, indicating the development of a
pathological model, while this parameter decreased by 53.3% in the Lish-6 drug group (p=0.05).
Conclusion:Lish-6 traditional drug has the effect of reducing rectal temperature, IL-1β, PGE2 and IL-6 cytokines during
lipopolysaccharide-induced febrile pathology model.
- Full text:2025052715382856041142-147.pdf
