Correlation between FTO gene rs9939609, rs17817449 polymorphisms and, obesity
- VernacularTitle:Таргалалтын үед FTO генийн rs9939609, rs17817449 полиморфизмын илрэлийг судалсан дүн
- Author:
Yumchinsuren Ts
1
,
2
;
Dolgion D
2
;
Yesukhei E
2
;
Baljinnyam T
3
;
Enkhmend Kh
2
;
Ganchimeg D
2
;
Gantogtokh D
2
;
Otgongerel N
2
;
Batbold B
1
,
2
;
Shiirevnyamba A
1
;
Tulgaa L
2
Author Information
1. Department of Health Research, Graduate School, MNUMS
2. Institute of Medical Sciences, Ministry of Economy and Development
3. Department of Molecular biology and Genetics School of Biomedicine, MNUMS
- Publication Type:Journal Article
- Keywords:
Overweight;
Single nucleotide polymorphism;
Genotype;
Allele;
Genetics
- From:
Mongolian Journal of Health Sciences
2025;85(1):136-141
- CountryMongolia
- Language:Mongolian
-
Abstract:
Background: In 2022, the World Health Organization (WHO) reported that globally, 2.5 billion (43%) of adults aged
18 and older were overweight, with 890 million (16%) of these individuals classified as living with obesity. Some genes
such as the FTO gene are strongly associated with obesity and overweigh. The FTO protein is crucial in regulating food
consumption, appetite, energy equilibrium, and expenditure.
Aim: The identify single nucleotide polymorphisms rs9939609 and rs17817449 of the FTO gene, which are associated
with obesity, and to study their correlation with antropometric measurements and some laboratory test parameters.
Materials and Methods:According to the inclusion and exclusion criteria, 50 obese (BMI >30 kg/m²) were included in
the case group, and 50 relatively healthy and normal weight (BMI 18.5-24.9 kg/m²) were enrolled in the control group,
for a total of 100 people matched for age and gender (1:1). We took physical measurements and collected peripheral blood
samples after obtaining informed consent from each participant. Laboratory analyses assessed some parameters of lipid
and glucose metabolism. We used the PCR-RFLP technique on two genotype SNPs. A p-value below 0.05 was considered
a statistically significant result.
Results: In this study, including 100 people aged 23 to 75, the mean age was 46.81±11.54 years, with 60% being female.
In terms of antropometric measurements, body mass index, waist circumference, and arterial pressure were markedly
elevated in the case group compared to the control group (p<0.001). In laboratory measures, fasting blood glucose,
cholesterol, and mean LDL mean levels were statistically significantly higher in the case group compared to the control
group. On the other hand, HDL cholesterol levels were lower in the case group compared to the control group. The FTO
gene rs9939609 single nucleotide polymorphism was identified in 62% of the total study individuals as TT, 35% as AT,
and 3% as AA genotypes. Also, FTO gene rs17817449 single nucleotide polymorphism was identified in 62% of the total
study individuals as TT, 33% as AT, and 5% as AA genotypes.
Conclusion: The rs9939609 AT/AA genotype of the FTO gene elevates the risk of obesity and is associated with increased body weight, waist circumference, and BMI.
- Full text:2025052715344425349136-141.pdf
