Result of a study on some effects of (Allium polyrhizum Turcz. ex Regel) preparation on a type 2 diabetic model
- VernacularTitle:Таанын (Allium polyrhizum Turcz. ex Regel) бэлдмэлийн чихрийн шижин хэв шинж 2-ын эмгэг загварт үзүүлэх зарим нөлөөг судалсан дүн
- Author:
Oyun-Erdene R
1
,
2
;
Gerelt Borjikhan
2
;
Munkhtsetseg J
1
Author Information
1. Department of Biochemistry, School of Biomedicine, MNUMS
2. Institute of Mongolian Medicinal Chemistry, Inner Mongolia University
- Publication Type:Journal Article
- Keywords:
Allium polyrhizum Turcz.ex Regel;
Wistar rat;
Diabetes
- From:
Mongolian Journal of Health Sciences
2025;85(1):130-135
- CountryMongolia
- Language:Mongolian
-
Abstract:
Background: Diabetes mellitus (DM) is a complex metabolic disorder involving many organs and can devastate the
lives of affected individuals. It is characterized by chronic high blood glucose that could lead to morbidity and mortality.
The number of people suffering from diabetes worldwide is increasing at an alarming rate. It is predicted that about 366
million people are likely to be diabetic by the year 2030. Since all of the previous studies have focused on the therapeutic
role of (Allium polyrhizum Turcz. ex Regel) preparations in diabetes mellitus, we investigated the preventive effect of oral
administration of (Allium polyrhizum Turcz. ex Regel) extract on the changes of biochemical factors and histopathology
alterations in hepatic tissue caused by diabetes. Therefore, this study aimed to investigate the effect of water extract (Allium polyrhizum Turcz. ex Regel) on the metabolism of rats with diabetes induced by a high-fat diet and streptozotocin.
Aim: To investigate the antidiabetic properties of aqueous extract of (Allium polyrhizum Turcz. ex Regel) and its beneficial
effect on hematological parameters in streptozotocin-induced diabetic rats.
Materials and Methods:Experimental was performed at the Institute of Mongolian Medicine and Chemistry, Inner
Mongolia University. Male Wistar rats weighing (180 g) were obtained from The Animal Experimental Unit of Mongolia
Medicine and Chemistry Research Center, Inner Mongolia University.
The rats were housed in well-aerated individual cages in an animal room and maintained in a temperature-controlled
room (24±25°C) with a 12 h light/12 h dark cycle, 50-60 % humidity. They were fed with normal commercial chow and
water ad libitum. Throughout the experiments, animals were processed according to the suggested international ethical
guidelines for the care of laboratory animals, and all experimental procedures were approved by the Animal Care and Use
Committee of Inner Mongolia University.
After 4 weeks, the rats were fasted for 8 h before blood sampling, water was not restricted. Blood samples were collected
from the orbital venous plexus.
Results: The blood glucose level was significantly increased in model group 24.14±2.28 mmol/L, to Control group
5.31±0.49 mmol/L. Oral administration of Allium polyrhizum Turcz.ex Regel treated group 10.5±4.05 mmol/L, Metformin treated group 9.05±2.71 mmol/L resulted in significantly decreased blood glucose levels less model group.
Conclusion: The results of this study indicate that Allium polyrhizum Turcz.ex Regel possesses hypoglycemic, hypolipidemic, and antioxidant effects in STZ-induced diabetic rats and therapy of diabetes and its complications especially when
used for a longer period.
- Full text:2025052715292722717130-135.pdf
