Analysis of peripheral blood genetic material damage in children with vascular malformations after interventional procedures
10.13491/j.issn.1004-714X.2025.02.001
- VernacularTitle:脉管畸形儿童患者介入术后外周血遗传物质损伤分析
- Author:
Yuelong SHI
1
;
Ying PANG
2
;
Zhanchun GUO
2
;
Ya MA
1
;
Yingmin CHEN
3
,
4
;
Xiaoshan WANG
1
;
Rui CHEN
1
Author Information
1. College of Preventive Medical Sciences (Institute of Radiation Medicine), Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117 China.
2. Tengzhou Center for Disease Control and Prevention, Zaozhuang 277599 China.
3. College of Preventive Medical Sciences (Institute of Radiation Medicine), Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117 China
4. School of Public Health, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117 China.
- Publication Type:OriginalArticles
- Keywords:
Vascular malformation;
Interventional procedure;
γ-H2AX;
Chromosomal aberration
- From:
Chinese Journal of Radiological Health
2025;34(2):149-154
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe changes in genetic material in the peripheral blood of pediatric patients with vascular malformations after interventional procedures. Methods A total of 108 children with vascular malformations who underwent interventional procedures at Shandong University Affiliated Children’s Hospital between February 2021 and January 2024 were selected as the research subjects. Clinical data and peripheral venous blood samples before and after the interventional procedures were collected from the children. Two biological indicators, γ-H2AX and peripheral blood lymphocyte chromosomal aberration (CA), were used to determine the levels of genetic material damage in children with vascular malformations before and after interventional procedures. Results The median age of the children was 7 years and the median body weight was 27 kg. The median dose-area product (DAP) was 24.20 Gy·cm2 and the median DAP/kg was 1.04 Gy·cm2/kg. The incidence rates of both γ-H2AX foci and CA in children with vascular malformations significantly increased after the interventional procedures (Z = 5.924, P < 0.001; Z = 8.515, P < 0.001). The incidence of postoperative CA in 7 children were significantly higher than that in others, approaching or exceeding 4%. The incidence rates of postoperative γ-H2AX foci and CA in children with DAP/kg ≥ 1 Gy·cm2/kg were significantly higher than those in children with DAP/kg < 1 Gy·cm2/kg (U = 7.586, P = 0.031; U = 6.835, P = 0.009). No significant differences were observed in the incidence rates of postoperative γ-H2AX foci and CA among subgroups based on age, body weight, or surgical site. A positive correlation was observed between the difference in the incidence rates of γ-H2AX foci before and after the procedure and DAP/kg (R = 0.493, P = 0.027). Conclusion Ionizing radiation exposure during interventional procedures can increase peripheral blood genetic material damage levels in children with vascular malformations, and the damage levels show a correlation with the radiation dose, with some children being abnormally sensitive. Further research is needed to explore the influencing factors for genetic material damage in children with vascular malformations after interventional procedures, which is of great significance for reducing long-term cancer risks and achieving personalized treatment strategies.
