A potential effect of Yaman serdeg-3 with supplemental ingredients in a gallbladder injury model
- VernacularTitle:Нэмэрт ямаан сэрдэг-3 найрлагын цөсний эмгэг загварт үзүүлэх зарим үр дүн
- Author:
Munkhjargal R
1
,
2
;
Chimedragchaa C
3
;
Dolgormaa D
4
;
Tuul Kh
5
;
Dorjbat S
1
Author Information
1. Department of Mongolian Medicine Study, International School of Mongolian Medicine, MNUMS
2. Department of Traditional Medicine, The First Central Hospital of Mongolia
3. Institute of Traditional Medicine and Technology of Mongolia
4. National Forensic Agency of Mongolia
5. Otoch Manramba University
- Publication Type:Journal Article
- Keywords:
Saussuraea amara;
Liver;
Gallbladder;
Yaman serdeg
- From:
Mongolian Journal of Health Sciences
2025;85(1):91-95
- CountryMongolia
- Language:Mongolian
-
Abstract:
Background:Social development due to fat, fast food, obesity and physical exercise depended on chronic cholecystitis
and gallstones, still getting younger in recent years. Yaman Serdeg-3 is used in Mongolian Traditional Medicine for the
liver and gallbladder and has been studied to support the excretion of bile. We have created a compound recipe, Yaman
Serdeg-3 of Mongolia Traditional medicine, added Saussurea amara (L)DC herbal. Saussurea amara (L). DC is high in
biologically active compounds, and pharmacology has investigated the bile-expelling action and the effects of the plant
on cell growth. Chronic cholecystitis is a common chronic disease of the biliary tract in clinical patients. Symptoms can
be seen in right upper abdominal cramps; some patients can be accompanied by abdominal muscle rigidity, the primary
disease. It is caused by a large amount of bile blocking the patient’s gallbladder after the stone blocks the gallbladder duct.
In the sac, induced acute cholecystitis was again caused by pathogenic factors to form the disease.
Aim:Elucidating the effects of supplemental Yaman serdeg-3 in a gallbladder injury model.
Materials and Methods:We received permission for animal experimentation from The Ethics Committee of Mongolia
National University of Medical Sciences on the 10th of June 2022. The group created a model gallbladder disease with
0.5% a-naphthyl isothiocyanate [C11H7N5] dose (60 ml/kg), treatment with compound recipe Yaman Serdeg-3 (NYS-3)
high dose (2.025 g/ml), medium dose (1.35g/ml), low dose (0.675g/ml), that used to compare URSO 250 (0.0042g/ml) for
21 days. The third group created a model liver disease with a 40% Carbon tetrachloride [CCl4] dose (4 ml/kg), treatment
with compound recipe NYS-3 high dose (2.025 g/ml) and that was used to compare Hu gan pian (0.046g/ml) of China
medicine for 21 days. Liver tissue pathological sections were collected quickly after blood collection in rats. The liver,
stomach, and duodenum tissue on the right page were immersed in 10% neutral formalin and fixed for pathology.
Histological examination: The fixed tissue was trimmed, dehydrated, embedded, and cut. After slides, HE staining, sealing, and other procedures, an optical microscope was used to observe.
Results: In our study, the structure of the liver tissue cells in the high-dose group of Yaman serdeg-3 was preserved, the
vessels had irregular blood vessels, and there was significant infiltration of chronic inflammation in the triple bypass. In
this group, we divided the Yaman serged-3 into three groups: low-dose, medium-dose, and high-dose. In the model group
with liver tissue analysis, the low-dose and medium-dose groups had fewer chronic inflammatory cells in triads and interstitial cells. In contrast, the fact that the high-dose group of Yaman serdeg-3 showed sparse trigeminal and interstitial
and very few chronic inflammatory cells indicates that our study met its objectives, and the tissue analysis showed that
the high-dose group was more effective.
Conclusion: During the acute and toxic liver disease model in rats, the inflammation process in the liver cells was high,
and watery changes and fatty changes damaged the liver tissue. It has been confirmed that traditional herbal medicine, Yaman serdeg-3, reduced protein and fatty tissue changes in the hepatocyte membrane and accelerated liver and biliary tract
regeneration. Furthermore, our study has shown that Yaman serdeg-3 may have stimulated bile secretion dose-dependently and accelerated hepatocyte regeneration. Also, liver tissue analysis of the control group showed significant inflammation in the triad and interstitial cells; blood vessels were filled with blood, and cell structure was preserved. In contrast, the
comparison drug group had significant triad inflammation and fewer inflammatory cells in the interstitial cells.
- Full text:202505271449089398391-95.pdf
