Study on association between insulin resistance and intermediate risk factors for non-communicable diseases
- VernacularTitle:Инсулинд дөжрөлийн эрсдэл ба халдварт бус өвчний завсрын эрсдэлт хүчин зүйлсийн хамаарлыг судалсан дүн
- Author:
Khangai E
1
;
Batzorig B
2
;
Bayarbold D
3
;
Enkhtur Ya
4
;
Altaisaikhan Kh
5
;
Oyunsuren E
3
;
Oyuntugs B
5
Author Information
1. Department of Family Medicine, MNUMS
2. Department of Epidemiology and Biostatistics, MNUMS
3. Ministry of Health
4. School of Medicine, MNUMS
5. Department of Endocrinology, MNUMS
- Publication Type:Journal Article
- Keywords:
Triglyceride-glucose index;
Hypertension;
Central obesity;
Diabetes
- From:
Mongolian Journal of Health Sciences
2025;86(2):60-64
- CountryMongolia
- Language:Mongolian
-
Abstract:
Background:In Mongolia, the prevalence of non-communicable diseases and their intermediate risk factors has continuously
increased in recent years. From results of early detection and prevalence studies of non-communicable diseases in
Mongolia, studies linking intermediate risk factors to insulin resistance are scarce.
Aim:To identify the prevalence of insulin resistance among the population and study its connection with intermediate
risk factors of non-communicable diseases.
Materials and Methods:This study was approved by the MNUMS Ethics Committee on February 23, 2024 (2024/3-
02), and was conducted based on the data of participants who took part in the “Population-based Preventive and Early
Detection Screening of Infectious and Non-Infectious Diseases” organized by the Mongolian government from 2022 to
2023. Insulin resistance was identified using the triglyceride-glucose index (TyG), calculated by the formula Ln [fasting
triglycerides (mg/dL) × fasting glucose (mg/dL) / 2]. “Ln” refers to the natural logarithm, based on Euler’s number, approximately
2.71828. TyG levels were classified into low risk (<8.5), medium risk (8.5-9.0), and high risk (>9.0). Defined
intermediate risk factors for non-communicable diseases according to stages of hypertension and diabetes.
Results:The mean age of participants was 44.3±15.2 years, with 39.2% (n=49,270) male and 41.4% (n=49,749) residing
in urban areas. Among the participants, 59.1% had overweight or obesity, 23.6% had diabetes or impaired fasting glucose,
61.4% had hypertension, and 19.7% had elevated triglycerides. Analyzing by levels of insulin resistance risk, 62.8% of
the population had low risk, 22.5% medium risk, and 14.7% high risk. Comparing systolic blood pressure across levels
of insulin resistance risk showed that even without central obesity or diabetes, as the level of insulin resistance increased,
the level of systolic blood pressure also increased (low risk group: 117.0±11.7, medium risk group: 121.1±10.9, high risk
group: 123.5±16.2 mmHg). Regression analysis of the risk of hypertension by insulin resistance risk level showed that the
risk increased with higher levels of insulin resistance (medium risk group OR=1.35, p<0.0001; high risk group OR=1.63,
p<0.0001).
Conclusion:22.5% of the population is at medium risk and 14.7% at high risk of insulin resistance. The increase in hypertension
risk with higher insulin resistance levels is statistically significant, independent of central obesity and diabetes
stages.
- Full text:202505271355069758060-64.pdf
