Screening for asymptomatic cardiac ventricular dysfunction in diabetic subjects
- VernacularTitle:Зүрхний ховдлын үйл ажиллагааны шинж тэмдэггүй алдагдлыг чихрийн шижинтэй үйлчлүүлэгчдэд илрүүлсэн нь
- Author:
Tsolmon U
1
;
Chingerel Kh
1
;
Burmaa B
1
;
Sumiya Ts
1
;
Pagmadulam S
2
;
Chuluuntsetseg O
3
;
Enkhjargal Yu
4
Author Information
1. Department of Cardiology, School of Medicine, MNUMS
2. MJH, MNUMS
3. Regional diagnostic and treatment center, Dornod province
4. General hospital of Khuvsgul province
- Publication Type:Journal Article
- Keywords:
Biomarker;
Hypertension;
NT-pro BNP;
Risk factors
- From:
Mongolian Journal of Health Sciences
2025;86(2):55-59
- CountryMongolia
- Language:Mongolian
-
Abstract:
Background:Type 2 diabetes has increased risk of heart failure 2-4 times more than those in non-diabetic subjects. The
early detection of asymptomatic ventricular dysfunction by using NT-pro BNP test in diabetic patients is the best strategy
for decreasing morbidity and mortality of heart failure.
Aim:The aims of this study were to detect asymptomatic cardiac ventricular dysfunction by using NT-pro BNP test in
subjects with type 2 diabetes and to define the factors associated with elevated NT-proBNP.
Materials and Methods:This cross-sectional study was included diabetic and non diabetic subjects aged from 35- to 64
years, who had no clinical symptoms of heart failure. Cardiovascular risk factors were detected by clinical examinations.
NT-pro BNP determination was performed on an immunoassay analyzer (FIA1100, Getein Bio Medical Inc, China),
which uses reagent strip to obtain quantitative NT-pro BNP results in plasma. The cut-off point for NT-pro BNP was 300
pg/ml.
Results:A total of 536 subjects without clinical symptoms of heart failure were included in the study of which, 150 were
diabetic and 386 were non diabetic. The mean age was 52.8 ± 7.8 years and 281 (52.4%) were females. Cardiac ventricular
dysfunction was detected in 7.3% of diabetic and 5.2% of non diabetic subjects. Cardiac ventricular dysfunction in
diabetic subjects was increased with age and non-significantly higher in females than in males (8.3% vs 6.4%, p>0.05). In
the logistic regression analysis, uncontrolled hypertension (OR 3.80, 95% CI 1.07–13.44), long duration of disease (OR
5.30, 95% CI 1.36-20.66), and ageing (OR 5.40, 95% CI 1.29–22.88) were significantly correlated cardiac ventricular
dysfunction in subjects with type 2 diabetes.
Conclusion:Cardiac ventricular dysfunction in subjects with type 2 diabetes was detected 1.4 times more than those
in non diabetic subjects. The likelihood of positive NT-pro BNP test in subjects with type 2 diabetes was independently
(p<0.05) associated with advanced age, uncontrolled hypertension and long duration of diabetes.
- Full text:202505271344065911355-59.pdf
