Detection of Small Intestinal Bacterial Overgrowth in Patients with Dyspepsia
- VernacularTitle:Гэдэсний биж шинж илэрсэн үйлчлүүлэгчдэд нарийн гэдэсний бактерийн хэт өсөлтийг илрүүлсэн дүн
- Author:
Sarangerel U
1
;
Sainzaya B
1
;
Khishigt N
1
;
Amgalanzaya E
2
,
3
;
Byambajav Ts
1
,
4
;
Sarantuya G
1
,
4
;
Bira N
1
,
4
Author Information
1. Endoscopy Unit, Mongolian-Japanese Hospital, MNUMS
2. Clinical Central Laboratory, Mongolian-Japanese Hospital, MNUMS
3. Department of Microbiology, Infection Prevention and Control, School of Biomedicine, MNUMS
4. Department of Gastroenterology, School of Medicine, MNUMS
- Publication Type:Journal Article
- Keywords:
SIBO;
Small intestinal bacterial overgrowth;
Hydrogen breath test;
Bloating;
Gut microbiota
- From:
Mongolian Journal of Health Sciences
2025;86(2):46-50
- CountryMongolia
- Language:Mongolian
-
Abstract:
Background:Small intestinal bacterial overgrowth (SIBO) is characterized by symptoms such as malabsorption, nutrient
deficiencies, bloating, and abdominal pain. It can occur independently or in association with other gastrointestinal
disorders. This study aims to determine the prevalence of SIBO in patients with digestive complaints, evaluate diagnostic
outcomes, and analyze the composition and types of pathogenic bacteria present in the small intestine.
Materials and Methods:A single-center, cross-sectional study was conducted at the Mongolian-Japanese Hospital, enrolling
a total of 46 participants. SIBO was diagnosed using the hydrogen breath test (H₂BT) with lactulose/glucose as
substrates. Among the 27 diagnosed cases, 5 patients were randomly selected for microbiological analysis of small intestinal
contents.
Results:SIBO was detected in 58.7% of the study participants. Among the 5 patients who underwent microbiological
analysis, 80% (4/5) tested positive for pathogenic bacteria. The identified pathogens included: Gram-positive bacteria:
Staphylococcus aureus (S. aureus); Gram-negative bacteria: Klebsiella pneumoniae (K. pneumoniae); Antibiotic-resistant
bacteria: Methicillin-resistant Staphylococcus aureus (MRSA); Fungi: Candida albicans (C. albicans). The remaining
20% (1/5) had a baseline H₂BT value exceeding twice the standard threshold despite no detected pathogens.
Conclusion:SIBO is highly prevalent among patients with digestive complaints and may be associated not only with
bacterial infections but also fungal overgrowth. Therefore, a multidisciplinary treatment approach, including antibiotics,
dietary modifications, probiotics, and antifungal therapy, is necessary. While the hydrogen breath test is an effective diagnostic
tool for SIBO, standardization of diagnostic protocols is required for improved accuracy.
- Full text:20250527132500708046-50.pdf
