The Relationship Between Metabolic Syndrome and Hyperferritinemia
- VernacularTitle:Бодисын солилцооны хам шинж ба гиперферритинеми хоорондын хамаарлыг судалсан үр дүн
- Author:
Ankhbayar B
1
,
2
;
Chuluunbileg B
3
;
Amartaivan J
4
;
Nyamdorj D
5
;
Sarantuya E
6
;
Uurtuya Sh
6
,
7
Author Information
1. Department of Health Sciences, Graduate School, MNUMS
2. Meltes Med Hospital
3. Zaigal Research Institute NGO
4. Munkh-Onich Hospital
5. Department of Anatomy, School of Bio-Medicine, MNUMS
6. Department of Medical Ethics and Education, Graduate School, MNUMS
7. Institute of Biomedical Sciences, MNUMS
- Publication Type:Journal Article
- Keywords:
Ferritin;
Obesity;
Hyperglycemia
- From:
Mongolian Journal of Health Sciences
2025;86(2):30-35
- CountryMongolia
- Language:Mongolian
-
Abstract:
Background:Hyperferritinemia, characterized by elevated serum ferritin levels, affects approximately 5–25% of the general
population. Given the frequent coexistence of liver iron overload syndrome and metabolic syndrome—both of which
significantly contribute to global morbidity and mortality—it is essential to investigate their interconnections. However,
there is a lack of sufficient evidence, both in Mongolia and internationally, regarding the relationship between iron storage
indicators, metabolic syndrome, and its components. A deeper understanding of iron’s role in disease progression is
needed.
Aim:This study aims to assess the association between hyperferritinemia and metabolic syndrome parameters.
Materials and Methods:A cross-sectional analytical observational study was conducted on 159 male participants who
met the inclusion criteria. Data were collected using a standardized questionnaire, and anthropometric measurements
were taken. Blood samples were analyzed to determine glucose, triglyceride, total cholesterol, and high-density lipoprotein
(HDL) levels using an automated biochemical analyzer. Serum ferritin concentrations were measured via the ELISA
method (DRG Instruments GmbH, Germany), with hyperferritinemia defined as a serum ferritin level exceeding 400 ng/
ml. Metabolic syndrome was diagnosed based on the Harmonized criteria. Statistical analyses included the chi-square
test and Fisher’s exact test for categorical variables, the Mann-Whitney U test for non-normally distributed data, and
Spearman’s correlation test to assess relationships between glycemic levels, lipid parameters, and metabolic syndrome
components.
Results:The findings indicate that 59 participants (37.1%) had metabolic syndrome, while 33 (20.8%) presented with
hyperferritinemia. The presence of metabolic syndrome and hyperglycemia increased the likelihood of developing hyperferritinemia
by 3.4 and 3.7 times, respectively, whereas abdominal obesity raised the risk by 2.2 times.
Conclusion:There was a significant correlation between serum ferritin levels and certain parameters of metabolic syndrome
among the male participants in this study.
- Full text:202505271304191446530-35.pdf
