The significance of exhaled nitric oxide in the diagnosis of asthma
- VernacularTitle:Астмын оношилгоонд амьсгалаар ялгарах азотын ислийн ач холбогдлыг судалсан дүн
- Author:
Densenbal D
1
,
2
;
Solongo B
1
,
2
;
Ankhbold G
3
;
Amarsanaa O
4
;
Battsengel Ts
5
;
Zesemdorj O
6
;
Janchivdorj Z
1
;
Ankhil L
1
;
Tseepil E
7
;
Odonchimeg B
5
;
Sarantuya J
8
;
Ichinnorov D
1
,
2
Author Information
1. Department of Pulmonary and Allergy School,l of Medicine, MNUMS
2. Mongol Japan Hospital, MNUMS
3. Psychiatric National Health Center
4. Shargaljuut Hot Spring Resort
5. Center of Pulmonary and Allergy, First State Hospital
6. Department Clinical Laboratory School of Medicine, MNUMS
7. Department of Respiratory disease, Second State Hospital
8. Department Molecule Biology and Genetic, School of Biomedicine, MNUMS
- Publication Type:Journal Article
- Keywords:
Allergy;
Asthma;
Diagnosis;
Eosinophilia;
Spirometry
- From:
Mongolian Journal of Health Sciences
2025;86(2):14-18
- CountryMongolia
- Language:Mongolian
-
Abstract:
Background:Asthma is a chronic inflammatory disease characterized by bronchoconstriction and breathing difficulties,
which can be triggered by both allergic and non-allergic mechanisms. In allergic asthma, a hyperreactivity reaction
occurs, leading to an increase in fractional exhaled nitric oxide (FeNO) levels. Therefore, FeNO is used to differentiate
allergic and non-allergic types of asthma. In recent years, studies have been conducted to assess FeNO as an indicator of
treatment effectiveness and symptom control. Our goal is to introduce FeNO measurement in Mongolia for the first time
and utilize it for asthma diagnosis and treatment outcome evaluation.
Aim:Study of FeNO levels in Asthma Diagnosis in Relation to Laboratory Findings and Lung Function
Materials and Methods:This study included a total of 70 adult patients (18 years and older) with asthma who visited the
Outpatient Clinic of Mongolia-Japan Hospital and Shargaljuut Spa Clinic from May to December 2024. Based on their
allergic history, total IgE levels, and peripheral blood eosinophil count, participants were classified into allergic (>5%)
and non-allergic (<5%) asthma. The study aimed to determine the diagnostic specificity and sensitivity of FeNO levels.
Asthma control levels were assessed using the Asthma Control Test (ACT), lung function was evaluated using spirometry,
and exercise capacity was measured with the 6-minute walk test.
Results:In a single measurement, there were no differences between the allergic and non-allergic groups in parameters
other than total IgE, peripheral blood eosinophil count, and FeNO levels. For diagnosing the allergic form of asthma, at
a FeNO level of 25 ppb, sensitivity (Se) was 0.68, specificity (Sp) was 0.30 (p=0.008); at 40 ppb, Se was 0.77, Sp was
0.31 (p=0.001); and at 50 ppb, Se was 0.74, Sp was 0.33 (p=0.001). Lung function and exercise capacity were similar in
both asthma groups.
Conclusion: The sensitivity of FeNO in distinguishing between allergic and non-allergic forms of asthma is 67-81%, and
its sensitivity tends to increase as the FeNO level rises. By distinguishing the allergic type in which inhaled corticosteroids
are more effective, the outcome of asthma treatment can be predicted in advance based on the FeNO level.
- Full text:20250527122917284314-18.pdf
