Research progress of new adjuvants in development of SARS-CoV-2 vaccines
10.13200/j.cnki.cjb.004489
- VernacularTitle:新型佐剂在SARS-CoV-2疫苗开发中的研究进展
- Author:
SU Linjia
- Publication Type:Journal Article
- Keywords:
Adjuvants;
SARS-CoV-2 vaccines;
Immune response;
Broad spectrum vaccine;
Delivery system
- From:
Chinese Journal of Biologicals
2025;38(05):624-629
- CountryChina
- Language:Chinese
-
Abstract:
Vaccination is the most cost-effective strategy to prevent and control SARS-CoV-2 infection, which plays an importantrole in maintaining global public health and ensuring human health. Adjuvants, as crucial components in vaccine development,can make up for the potential antigen immunogenicity deficiencies by enhancing the speed, intensity and persistence ofimmune response, and significantly improve the efficacy of vaccines, being a pivotal role in improving the immune effect ofSARS-CoV-2 vaccines. There are many types of adjuvants, which are suitable for different types of vaccines. For example,the inactivated SARS-CoV-2 vaccine mostly uses aluminum adjuvant, the recombinant protein vaccines adapt to compositeadjuvants, and the mRNA vaccines rely on lipid nanoparticle(LNP) delivery platform. In this paper, the classification andmechanism of adjuvants, their application in vaccines and new ideas for development of broad-spectrum SARS-CoV-2 vaccineadjuvants were reviewed, providing references for preparing innovative adjuvants with good safety and effectiveness, so as tocontinuously improve the immune efficacy of SARS-CoV-2 vaccines and cope with the continuous variation of SARS-CoV-2.
