A Study on Factors Influencing Outcomes in Patients Diagnosed with Sepsis and Septic Shock in the Intensive Care Unit of the Mongolia- Japan Hospital
- VernacularTitle:Монгол-Япон эмнэлгийн эрчимт эмчилгээний тасагт үжил, үжлийн шок оношоор хэвтэн эмчлүүлэгсдийн тавиланд нөлөөлж буй хүчин зүйлсийн судалгаа
- Author:
Erkhembileg Sh
1
;
Erdenetuya E
1
;
Sain-Yeruult E
2
;
Tamir L
2
Author Information
1. Resident Doctors in Critical Care Medicine, MNUMS
2. Department of Intensive Care, Mongolia-Japan Hospital, MNUMS
- Publication Type:Journal Article
- Keywords:
Lactate level, multiple organ dysfunction, number of infection foci, platelet abnormality, sepsis, septic shock.
- From:
Mongolian Journal of Health Sciences
2025;87(3):228-232
- CountryMongolia
- Language:Mongolian
-
Abstract:
Background:Sepsis is a life-threatening condition caused by a dysregulated
host response to infection, leading to tissue and organ damage.
Globally, over 19 million people are affected by sepsis each year,
with approximately 6 million deaths, making it the third leading cause
of mortality (25%). Identifying factors influencing patient outcomes in
sepsis and septic shock is therefore of critical importance.
Aim:To investigate the factors associated with outcomes in patients
admitted to the Intensive Care Unit (ICU) of the Mongolia-Japan Hospital
(MJH) with diagnoses of sepsis and septic shock.
Materials and Methods:A retrospective study was conducted on patients
admitted to the ICU of MJH with sepsis or septic shock during
2023–2024. We analyzed patient data including pre-existing comorbidities,
number of infection foci, presence of multiple organ dysfunction,
and initial laboratory parameters to determine associations with patient
outcomes.
Results:Among 430 patients admitted to the ICU during the study period,
136 (31.6%) were diagnosed with sepsis or septic shock. Of these,
94 patients (69.1%) recovered and 42 (30.8%) died. No significant differences
were found between survivor and non-survivor groups in terms
of comorbidities, white blood cell count, neutrophils, lymphocytes, mature
granulocytes, C-reactive protein, or creatinine levels. However,
multiple organ dysfunction (p<0.000), infection foci ≥2 (p<0.001), lactate
≥2 mmol/L (p<0.002), and platelet abnormalities (p<0.014) were
significantly associated with mortality. The most common sources of
infection were intra-abdominal infections (25.7%), pneumonia (25%),
skin and soft tissue infections (22.5%), urinary tract infections (16.1%),
abscesses (7.35%), tuberculosis (2.2%), and catheter-related bloodstream
or neurologically-origin infections (0.73%).
Conclusion:Intra-abdominal infections and respiratory tract infections
were the most common sources of sepsis among ICU patients. Multiple
organ dysfunction, having two or more infection foci, elevated lactate
levels (≥2 mmol/L), and platelet abnormalities were found to significantly
increase the risk of mortality in patients with sepsis and septic shock.
- Full text:2025052422511104343228-232.pdf
