Effects of Jur ur-4 granules on a Type 2 Diabetes Mellitus rat Model
- VernacularTitle:Жүр үр-4 тангаас гарган авсан уусдаг мөхлөгийн чихрийн шижин-2 хэв шинжийн эмгэг загварт үзүүлсэн зарим үр дүн
- Author:
Anu A
1
;
Myadagbadam U
1
;
Chimedragchaa Ch
1
Author Information
1. Institute of Traditional Medicine and Technology
- Publication Type:Journal Article
- Keywords:
Streptozotocin, granule, traditional medicine, diabetic mellitus
- From:
Mongolian Journal of Health Sciences
2025;87(3):60-64
- CountryMongolia
- Language:Mongolian
-
Abstract:
Background:In traditional medicine, Jur Ur-4 Tang, which is widely
used for the treatment of diabetes, has been technologically processed
and transformed into a modern pharmaceutical form as soluble granules.
Therefore, it is essential to evaluate the pharmacological effects
of the soluble granules derived from Jur Ur-4 Tang.
Aim:To study the
effect of granules extracted from Jur ur-4 Tang in a model of type 2 diabetes
mellitus in experimental rats.
Materials and Methods
T2DM in
rats was induced by a high-fat diet and a low-dose streptozotocin (STZ
35 mg/kg). Then, oral gavage administration of three different doses
of Granule (450 mg/kg, 900 mg/kg) was given to T2DM rats. Experimental
results showed that Granule dramatically reduced the levels
of fasting blood glucose, fasting blood insulin, and GLUT4.
Results::In the glucose tolerance test, granules at doses of 450 and 900 mg/
kg significantly reduced blood glucose levels at 60 and 120 minutes
(p < 0.01). Additionally, the soluble granules at all tested doses significantly
decreased blood insulin levels and increased GLUT4 expression
(p<0.01).
Conclusion:The granules lower blood glucose levels.
- Full text:202505232230468129860-64.pdf
