Impact of peripheral blood inflammatory markers on neovascular glaucoma secondary to diabetic retinopathy
10.3980/j.issn.1672-5123.2025.6.24
- VernacularTitle:外周血炎性指标对糖尿病视网膜病变继发新生血管性青光眼的影响
- Author:
Mingfang WANG
1
,
2
;
Wenwen ZHU
1
,
2
;
Deyu XIA
1
,
2
;
Dengrui XU
1
,
2
;
Yawen SHI
1
,
2
;
Hongchen FU
1
,
2
;
Qian ZHAO
1
,
2
;
Xiuyun LI
1
,
2
Author Information
1. Department of Ophthalmology, Affiliated Hospital(Clinical Medical College)of Shandong Second Medical University, Weifang 261041, Shandong Province, China
2. Shandong Second Medical University, Weifang 261053, Shandong Province, China
- Publication Type:Journal Article
- Keywords:
diabetic retinopathy;
neovascular glaucoma;
eosinophils;
monocyte-to-lymphocyte ratio;
inflammatory indicators
- From:
International Eye Science
2025;25(6):1005-1008
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the influence of relevant inflammatory markers in peripheral blood on the progression of neovascular glaucoma(NVG)secondary to diabetic retinopathy(DR)patients.METHODS: Retrospective case-control study. Patients were categorized into two groups based on the presence or absence of NVG: those with proliferative diabetic retinopathy(PDR)alone(PDR group, n=148)and those with NVG secondary to PDR(NVG secondary to PDR group, n=142). Peripheral blood inflammatory markers were evaluated, including white blood cell-related indices, neutrophil-to-lymphocyte ratio(NLR), platelet-to-lymphocyte ratio(PLR), monocyte-to-lymphocyte ratio(MLR), and systemic immune-inflammation index(SII). The distinctions in peripheral blood inflammatory markers between the two groups of patients and their relationships with NVG secondary to PDR were analyzed.RESULTS:No statistically significant differences were observed in basic characteristics between the two groups, confirming their comparability. However, significant differences were found in eosinophil percentage and MLR between the PDR group and the NVG secondary to PDR group(all P<0.05), with both values being significantly higher in the NVG secondary to PDR group. Multivariate Logistic regression analysis revealed that the eosinophil percentage and the MLR were factors influencing the development of patients with NVG secondary to PDR.CONCLUSION: Eosinophil percentage and MLR may be associated with the progression of PDR to NVG, and could serve as potential predictive markers for NVG development in PDR patients.
