Effects of nicotinamide mononucleotide on hypertensive rats
10.12206/j.issn.2097-2024.202412006
- VernacularTitle:烟酰胺单核苷酸口服给药对高血压大鼠的影响
- Author:
Yuchen WEI
1
;
Jiasheng TIAN
2
;
Daoxin WANG
2
;
Qisheng LING
2
;
Zhi WANG
2
;
Chaoyu MIAO
2
,
3
Author Information
1. School of Medicine, Shanghai University, Shanghai 200444, China.
2. Department of Pharmacology, Naval Medical University, Shanghai 200433, China.
3. School of Medicine, Shanghai University, Shanghai 200444, China
- Publication Type:Originalarticles
- Keywords:
NMN;
hypertension;
rat hypertension models;
organ damage;
lifespan
- From:
Journal of Pharmaceutical Practice and Service
2025;43(5):213-221
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of nicotinamide mononucleotide （NMN） on hypertensive rats. Methods Two rat hypertension models including spontaneously hypertensive rats（SHR）and two-kidney two-clip （2K2C） rats were used to be given single, long-term or lifelong administration of NMN respectively. NMN’s effects were assessed comprehensively by monitoring survival time, blood pressure levels, and the extent of organ damage in hypertensive model rats. Results It was revealed that NMN did not exhibit protective effects in terms of lowering blood pressure levels, reducing organ damage or increasing survival time in hypertensive rats. Conclusion This study suggested that NMN did not demonstrate anti-hypertensive effects in rat hypertension models and could provide valuable insights for future clinical observation on NMN.
