A study to determine the prognosis of prostate cancer recurrence
- VernacularTitle:Түрүү булчирхайн хорт хавдрын дахих прогнозыг тодорхойлсон нь
- Author:
Wei Liu
1
;
Bilegtsaikhan Ts
1
;
Shiirevnyamba A
1
Author Information
1. Graduate School, Mongolian National University of Medical Sciences
- Publication Type:Journal Article
- Keywords:
Prostate;
Cancer;
Gene;
TARBP1
- From:
Mongolian Journal of Health Sciences
2025;88(4):244-247
- CountryMongolia
- Language:Mongolian
-
Abstract:
Background:Prostate cancer is a common cancer in older men worldwide and is one of the most difficult cancers to
diagnose and treat clinically. Prostate cancer is caused by multiple risk factors and has been shown to occur through the
interaction and alteration of multiple genes. TARBP1 is an RNA-binding protein that is overexpressed in some tumors.
Aim:Identification of genes related to nucleotide metabolism that influence biochemical recurrence of prostate cancer
Materials and Methods:Genes related to nucleotide metabolism were identified using weighted gene co-expression
network analysis (WGCNA) from the Prostate Cancer Genome Atlas (TCGA-PRAD) database. Genes were identified
using differential gene expression analysis. Some of the differentially expressed genes were confirmed by immunohisto
chemistry (IHC) analysis of tumor tissues.
Results:Data from 481 prostate cancer patients and 51 healthy tissue samples from the Prostate Cancer Genome Atlas
database were analyzed. 105 genes related to nucleotide metabolism were identified that were statistically significantly
differentially expressed between prostate cancer and healthy tissue (P < 0.001). Five genes (RGS11, KAT2A, MXD3,
TARBP1, WFIKKN1) were identified as biomarkers for biochemical recurrence of prostate cancer. TARBP1 was significantly overexpressed in prostate cancer compared with healthy tissue.
Conclusions:In prostate cancer, the expression of some genes related to nucleotide metabolism is altered, and five genes
have been identified that predict the biochemical recurrence of prostate cancer. TARBP1 is highly expressed in prostate
cancer tissue.
- Full text:2025052216110538090244-247.pdf
